Photoredox-catalyzed difunctionalizations of alkenes with O-acyl hydroxylamine derivatives are described. The solvent tunes the outcome of these reactions. Diamidation and oxidative amidation of alkenes can be achieved in CHCN and DMSO, respectively. A variety of 1,2-diamidates and α-amino ketones bearing many functional groups are prepared using Ir(ppy) as the photocatalyst under visible light irradiation.

A radical relay strategy is described to synthesize functionalized β-amino alcohols. This strategy is enabled by photoredox-catalyzed and nitrogen-centered radical-triggered cascade reactions of styrenes (or phenylacetylenes), enol derivatives, and O-acyl hydroxylamines in DMSO. The broad synthetic application of this method is demonstrated by the reaction of structurally diverse reaction components, including complex molecular scaffolds. Multiple functional groups of the resultant highly functionalized β-amino alcohol derivatives facilitate their further transformations.

Ap ractical and efficient method hasb een developed for the preparation of polysubstituted furans by using av isible-light-promoted photoredox approach. The one-pot synthesis involves ar adical cyclization/deprotection/aromatization reactions equence that proceeds smoothly under mild conditions, which makes this transformation ap owerful tool for the synthesis of av ariety of highly substitutedf urans.