Depression is a progressive and chronic syndrome and commonly related to several neuropsychiatric comorbidities, of which depression is the most studied. Population-based studies have suggested a positive role of statins in ameliorating depression risk. However, the role of statins in the treatment of diabetes-related depression has not been well examined. Herein, we investigated the effects of lovastatin (LOV) on depressive phenotypes in streptozotocin-induced diabetic mice. The data suggested that the treatment of LOV at 10 or 20 mg/kg for 3 weeks markedly prevented diabetesassociated depressive behaviors reflected by better performance in the sucrose preference test, tail suspension test, and novelty-suppressed feeding test. The study further showed that these treatments improved the hippocampal neurogenesis as evidenced by increased bromodeoxyuridine-positive cells in the dentate gyrus with higher expression of mature brain-derived neurotrophic factor and increased phosphorylation of cAMP-response element-binding protein. As expected, diabetic mice treated with LOV showed significant improvement of hyperlipidemia rather than hyperglycemia. These results suggest that LOV may be employed as a drug for the treatment of diabetes-related depression.

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Affective touch plays an important role in human-robot interaction. However, it is challenging for robots to perceive various natural human tactile gestures accurately, and feedback human intentions properly. In this paper, we propose a data-driven affective computing system based on a biomimetic quadruped robot with large-format, high-density flexible pressure sensors, which can mimic the natural tactile interaction between humans and pet dogs. We collect 208-minute videos from 26 participates and construct a dataset of 1212 human gestures-dog actions interaction sequences. The dataset is manually annotated with an 81-tactile-gesture vocabulary and a 44-corresponding-dog-reaction vocabulary, which are constructed through literature, questionnaire, and video observation. Then, we propose a deep learning algorithm pipeline with a gesture classification algorithm based on ResNet and an action prediction algorithm based on Transformer, which achieve the classification accuracy of 99.1% and the 1-gram BLEU score of 0.87 respectively. Finally, we conduct a field study to evaluate the emotion regulation effects through tactile affective interaction, and compare it with voice interaction. The results show that our system with tactile interaction plays a significant role in alleviating user anxiety, stimulating user excitement and improving the acceptability of robotic dogs.

Background: Current FDA-approved label recommends polymyxin B dosing should be adjusted according to renal function, despite several studies proved poor correlation between polymyxin B PK and creatinine clearance. The study aims to assess the impact of renal function on polymyxin B metabolism and identify an alternate dosing strategy by population analysis. Methods: Blood samples from adult patients were collected at steady state during routine therapeutic drug monitoring. Nonlinear mixed effects modeling was employed to build a population PK model of polymyxin B. Monte Carlo simulations were performed to design polymyxin B dosing regimens across various renal function. Results: Pharmacokinetic analyses included 112 polymyxin B concentrations at steady state from 32 adult patients aged 37-93 received intravenous polymyxin B (100-200 mg/d). The creatinine clearance in patients was 5.91-244 mL/min. In the final population PK model, CrCL was the significant covariate on CL (typical value, 1.59 L/hr; between-subject variability, 13%). Mean (SD) individual empirical Bayesian estimates of CL was 1.75 (0.43) L/hr. A new dosing strategy combining the PK/PD targets and Monte Carlo simulation indicated that polymyxin B dose reductions improved the probability of achieving optimal exposures in simulated patients with renal insufficiency. For severe infections caused by organisms with MIC of ≥ 2 mg/L, though a high daily dose (e.g. 200mg/day) would possible for bacterial eradication, the risk of nephrotoxicity is significantly increased. Conclusion: A population PK model was established to develop individualized polymyxin B dosage regimens that the dose of polymyxin B should be adjusted according to CrCL.