Ischemia-reperfusion (I/R) is a pathological process that occurs in many organs and diseases. Reperfusion, recovery of blood flow, and reoxygenation often lead to reperfusion injury. Drug therapy and early reperfusion therapy can reduce tissue injury and cell necrosis caused by ischemia, leading to irreversible I/R injury. Ferroptosis was clearly defined in 2012 as a newly discovered iron-dependent, peroxide-driven, nonapoptotic form of regulated cell death. Ferroptosis is considered the cause of reperfusion injury. This discovery provides new avenues for the recognition and treatment of diseases. Ferroptosis is a key factor that leads to I/R injury and organ failure. Given the important role of ferroptosis in I/R injury, there is considerable interest in the potential role of ferroptosis as a targeted treatment for a wide range of I/R injury-related diseases. Recently, substantial progress has been made in applying ferroptosis to I/R injury in various organs and diseases. The development of ferroptosis regulators is expected to provide new opportunities for the treatment of I/R injury. Herein, we analytically review the pathological mechanism and targeted treatment of ferroptosis in I/R and related diseases from the perspectives of myocardial I/R injury, cerebral I/R injury, and ischemic renal injury.

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Abstract. Protecting one’s positive self-image from damage is a fundamental need of human beings. Forgetting is an effective strategy in this respect. Individuals show inferior recall of negative feedback about themselves but unimpaired recognition of self-related negative feedback. This discrepancy may imply that individuals retain negative information but forget that the information is associated with the self. In two experiments, participants judged whether two-character trait adjectives (positive or negative) described themselves or others. Subsequently, they completed old-new judgments (Experiment 2) and attribution tasks (Experiments 1 and 2). Neither old-new recognition nor source guessing bias was influenced by word valence. Participants’ source memory was worse in the negative self-referenced word processing condition than in the other conditions. These results suggest there is a self-serving bias in memory for the connection between valence information and the self.

Abstract:In practical optimization, a priority requirement for different objectives of multiple objective optimization problems should be considered. In this paper, the distributed power management of a Virtual Power Plant (VPP) with priority requirement is optimized by the compromised method. The operation optimization model of VPP is formulated as a fuzzy multiple objective optimization problem considering the satisfaction of customers and suppliers, the system stability, the power quality, and costs with operation limitations. The multiple objective optimization algorithm with the compromise of the satisfactory degree and the priority of objectives is studied based on the principle of two-step interactive satisfactory optimization. This method is also applied in a test system.