ObjectivesLung cancer is the most common and lethal malignancy worldwide. CEP55 was found to be overexpressed in multiple types of cancer. However, the expression pattern of CEP55 and its clinical significance in non-small-cell lung carcinoma (NSCLC) have not been investigated by immunohistochemistry.Materials and methodsIn this study, we analyzed 203 primary NSCLC specimens from Sun Yat-Sen University Cancer Center to investigate the clinical role of CEP55 in lung cancer. Tissue microarray was successfully generated for immunohistochemical evaluation. The correlation between CEP55 expression and clinical characteristics and survival was analyzed statistically. The predictive effect of CEP55 and APOBEC3B (AP3B) coexpression in lung cancer patients’ prognosis was evaluated.ResultsWe found that the CEP55 expression was commonly elevated in NSCLC tissues and overexpression of CEP55 was correlated with unfavorable prognosis in the patients with NSCLC. Furthermore, the combination of CEP55 and AP3B expression was significantly predictive of clinical outcome in all NSCLC patients.ConclusionCEP55 may act as a useful and novel prognostic biomarker for NSCLC. Further studies into the mechanism of CEP55 are warranted.

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Taking the Poiseuille flow of a molten polymer in parallel plates as the research object and polymethyl methacrylate (PMMA) as the research material, an all-atom analysis model of the molecular dynamic flow of polymer macromolecules is established according to the Navier slip law. The effects of wall wettability and external pressure on the wall slip behaviour of polymer macromolecules, as well as the spatial evolution process of the entanglement–unentanglement process of polymer chains near the wall under different shearing effects, were studied. The interface thermal resistance rule was explored, and an interface thermal resistance model considering the wall slip behaviour was established. Finally, a micro-injection experiment was used to verify the validity and accuracy of the model. The results show that when the wall is hydrophobic, the polymer melt exhibits significant wall slip. As the external pressure increases, the wall slip speed and the slip length increase. However, after a certain pressure is exceeded, the growth rate of the slip length is basically zero. As the external pressure increases, the PMMA molecular chains gradually start to separate, the single molecular chain becomes untangled from the entangled grid, and the chain detaches from the wall after exceeding a certain threshold. Wall slip reduces the interface thermal resistance between the solid–liquid interface and enhances the interface heat transfer performance. The interface thermal resistance value calculated by molecular dynamics can more accurately reflect the heat conduction rule of the solid–liquid interface at the micro/nanoscale than that measured by the thermal resistance experiment, indicating that the micro/nano interface thermal resistance obtained by molecular dynamics simulation is reliable.

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Moth-eye-mimicking nanoprotrusion arrays are typical bioinspired broadband antireflection patterns that improve the transmittance and visibility of optical devices by adjusting different geometrical parameters of nanostructures, such as diameter, height, shape, and periodic arrangement, and widely used in solar cells, electronic displays, and so on. Rapid, net-shape, less complicated, and low-cost fabrication of the glass-based moth-eye nanostructure array is a huge challenge. This work adopted the nanohole array template to transform the moth-eye nanostructures on the optical glass by hot embossing combined with ultrasonic-assisted demolding. To investigate the mode transition and filling behavior of the glass nanostructures when compressed into the nanoholes, we conducted a series of hot embossing tests with various processing parameters and characterized the geometrical morphology of the glass-based nanostructure array, such as height and shape. In these tests, surface defects such as nanocracks will occur when inappropriate processing parameters were applied and we evaluated the transmittance performance of defective and fine glass nanostructures and surface with no nanostructures to reveal the effect of nanostructures with different levels of quality on antireflection. This work provides an effective and environmental-friendly method for the fabrication of moth-eye nanostructure arrays with an improved antireflection performance.