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BACKGROUND/OBJECTIVESNon-alcoholic fatty liver disease (NAFLD) is becoming an important public health problem as metabolic syndrome and type 2 diabetes have become epidemic. In this study we investigated the protective effect of Cordyceps militaris (C. militaris) against NAFLD in an obese mouse model.MATERIALS/METHODSFour-week-old male ob/ob mice were fed an AIN-93G diet or a diet containing 1% C. militaris water extract for 10 weeks after 1 week of adaptation. Serum glucose, insulin, free fatty acid (FFA), alanine transaminase (ALT), and proinflammatory cytokines were measured. Hepatic levels of lipids, glutathione (GSH), and lipid peroxide were determined.RESULTSConsumption of C. militaris significantly decreased serum glucose, as well as homeostasis model assessment for insulin resistance (HOMA-IR), in ob/ob mice. In addition to lowering serum FFA levels, C. militaris also significantly decreased hepatic total lipids and triglyceride contents. Serum ALT activities and tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) levels were reduced by C. militaris. Consumption of C. militaris increased hepatic GSH and reduced lipid peroxide levels.CONCLUSIONSThese results indicate that C. militaris can exert protective effects against development of NAFLD, partly by reducing inflammatory cytokines and improving hepatic antioxidant status in ob/ob mice.

BACKGROUND/OBJECTIVES:Non-alcoholic fatty liver disease (NAFLD) is becoming an important public health problem as metabolic syndrome and type 2 diabetes have become epidemic. In this study we investigated the protective effect of Cordyceps militaris (C. militaris) against NAFLD in an obese mouse model. MATERIALS/METHODS: Four-week-old male ob/ob mice were fed an AIN-93G diet or a diet containing 1% C. militaris water extract for 10 weeks after 1 week of adaptation. Serum glucose, insulin, free fatty acid (FFA), alanine transaminase (ALT), and proinflammatory cytokines were measured. Hepatic levels of lipids, glutathione (GSH), and lipid peroxide were determined. RESULTS: Consumption of C. militaris significantly decreased serum glucose, as well as homeostasis model assessment for insulin resistance (HOMA-IR), in ob/ob mice. In addition to lowering serum FFA levels, C. militaris also significantly decreased hepatic total lipids and triglyceride contents. Serum ALT activities and tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) levels were reduced by C. militaris. Consumption of C. militaris increased hepatic GSH and reduced lipid peroxide levels. CONCLUSIONS: These results indicate that C. militaris can exert protective effects against development of NAFLD, partly by reducing inflammatory cytokines and improving hepatic antioxidant status in ob/ob mice.

Aggressive treatment of dyslipidemia is associated with the reduced risk for cardiovascular diseases in diabetic patients. The aim of this study was to investigate the effect of myricetin on dyslipidemia in animal model of type 2 diabetes. Four‐week‐old male C57BL/KsJ‐db/db mice (n=14) were fed AIN‐93G diet or diet containing myricetin (150 mg/kg) for 7 weeks after one week of adaptation. After the animals were sacrificed after an overnight‐fast, serum triglycerides, total cholesterol, and HDL‐cholesterol were measured by enzymatic methods. Atherogenic index (AI) was calculated as follows: [(Total cholesterol ‐ HDL‐cholesterol)/HDL‐cholesterol]. Myricetin decreased serum triglycerides and total cholesterol levels compared with the control group (p<0.05). Serum HDL‐cholesterol levels were not significantly different between the two groups. AI of the myricetin group was significantly lower than the control group. These results indicate that myricetin could be beneficial in management of type 2 diabetes by controlling dyslipidemia. This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (2012015763).