This is an open access article under the terms of the Creat ive Commo ns Attri bution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Network Security Situational Awareness (NSSA) is an important element in network security research.Predicting network security situational level can help grasp the network security situation. This study mainly focuses on the double-feedback Elman model. Firstly, NSSA was briefly introduced. Then, relevant indicators were selected to establish a security situational indicator system. A back-propagation neural network (BPNN) model was designed to evaluate the situational value. A dual-feedback Elman model was used to predict the future situational level. The actual network environment was built to conduct experiments. The results showed that the evaluation results of only three samples obtained by the BPNN model did not match the actual situation, with an accuracy of 90%, and the prediction results of only four samples obtained by the dual-feedback Elman model did not match the actual situation, with an accuracy of 96.67%. The experimental results verify the reliability of the network security situational level prediction method designed in this study. The NSSA method can be promoted and applied in practice. Povzetek: S pomočjo globokih nevronskih mrež so razvili metodo za napovedovanje glede varnosti v omrežjih.

Purpose Most of the existing studies focus on the early inflammation of rosacea, with few interventions on the later development of fibrosis and the relationship between thalidomide and rosacea. The purpose of this study was to construct a long-term induction model and explore the effects of thalidomide on the later stage of inflammation and early stage of fibrosis in rosacea. Patients and Methods BALB/c male mice were randomly divided into four groups: control group, control plus thalidomide group, LL-37 group and LL-37 plus thalidomide group, Intradermal and intraperitoneal injections were given. After repeated induction, skin changes were recorded by taking photos. The animals were sacrificed, the back skin was used for HE staining and VG staining to detect histomorphological characteristics. Immunofluorescence staining and Western blot were used to detect the expression of inflammatory and fibrosis-related factors. Results The results were compared with the early stage of the model, wherein the skin inflammation of the 20-day mice was more obvious with a trend of fibrosis. Compared with the control group, histopathological examination showed that the inflammatory cell infiltration in the LL-37 group was significantly increased, and the skin was thickened with collagen deposition. LL-37 induction significantly increased the expression of inflammatory markers (eg, TNF-α and IL-1β) and fibrotic markers (eg, COL1, α-SMA, vimentin and N-Cadherin). Intervention with thalidomide significantly reduced erythema, inflammatory cell infiltration, collagen deposition, and down-regulate the expression of inflammation and fibrosis related factors in rosacea mice. Conclusion The long-term continuous induction of LL-37 in mice could simulate the occurrence and development of rosacea, and thalidomide could ameliorate the rosacea induced by long-term exposure to LL-37 by regulating inflammatory infiltration, collagen deposition and fibrosis-related processes.

Successive years have witnessed our economy's sustainable and speedy growth; meanwhile, we have also accumulated a lot of problems, such as severe waste of resources and energies and grave environmental disruption, which hamper greatly our future development. As a kind of innovative economic operation model, circular economy proposes new content and requests for enterprise behaviour. This paper exploits the objects, principles and characteristics of enterprise behaviors under the mode of circular economy, applies game theory on their motives and expounds the importance of circular economy to the further development of an rational enterprise.

Background Verruca plana is a benign proliferation of the skin caused by human papilloma virus (HPV) infection. Fresh garlic can serve as an alternative therapy, and it has shown considerable effectiveness as a topical treatment for verruca plana. However, topical garlic treatment for verruca plana triggered Koebner phenomenon (KP), which has not been previously reported. Aim The aim of our report is to explore the possible causes of this adverse reaction. Method We here describe a 20‐year‐old female patient who developed a beaded rash after garlic treatment for facial wart plana, known as autoinoculation or KP. Results Garlic may have caused damage to the surrounding normal skin through primary irritation or allergic reactions. Then, the HPV virus on the primary verruca plana took the opportunity to spread to the surrounding skin injured by garlic stimulation, triggering the KP. Conclusion When using garlic to treat verruca plana, the operator needs to precisely apply the mashed garlic to the warts, and this treatment is strictly prohibited for patients who are allergic to garlic. Avoid such adverse reactions.