These results indicate that the systemic delivery of plasmid DNA targeting FAK function using cationic liposome as a gene carrier, represents a promising avenue for breast cancer therapy.

The quartz-crystal resonator is the core device for frequency control in modern communication systems and network technology. At present, in modern resonator blanks manufacturing, BOE solution is usually used as the etching solution, but its etching rate is relatively volatile, and the surface morphology of the blanks is prone to defects after etching, which brings certain difficulties to the deep-etching process of the wafer. To solve the above challenges, this paper systematically compares a BOE solution and anhydrous etching solution in terms of etching rate, surface morphology, and electrical properties of the blanks after etching. Seven groups of blanks were etched using different etching solutions with different etching conditions to verify their effect on the surface morphology and electrical properties of quartz blanks. The experimental results suggest that the application of anhydrous etching solution has achieved better surface morphology and electrical properties and can be more suitable for application in batch manufacturing. In general, when using anhydrous etching solution, it is possible to reduce surface roughness by up to 70% and equivalent resistance by 32%, and the etch rate is almost 10 times lower than BOE solution under the same temperature, which is more conducive to the rate control of wafers in the etching process.

Ovarian cancer is the most common cause of death from gynecologic malignancy. Deregulation of p53 and/or p73associated apoptotic pathways contribute to the platinum-based resistance in ovarian cancer. NOXA, a pro-apoptotic BH3only protein, is identified as a transcription target of p53 and/or p73. In this study, we found that genetic variants of Bcl-2 proteins exist among cisplatin-sensitive and -resistant ovarian cancer cells, and the responses of NOXA and Bax to cisplatin are regulated mainly by p53. We further evaluated the effect of NOXA on cisplatin. NOXA induced apoptosis and sensitized A2780s and SKOV3 cells to cisplatin in vitro and in vivo. The effects were mediated by elevated Bax expression, enhanced caspase activation, release of Cyt C and Smac into the cytosol. Furthermore, gene silencing of Bax or Smac significantly attenuated NOXA and/or cisplatin-induced apoptosis in chemosensitive A2780s cells, whereas overexpression of Bax or addition of Smac-N7 peptide significantly increased NOXA and/or cisplatin-induced apoptosis in chemoresistant SKOV3 cells. To our knowledge, these data suggest a new mechanism by which NOXA chemosensitized ovarian cancer cells to cisplatin by inducing alterations in the Bax/Smac axis. Taken together, our findings show that NOXA is potentially useful as a chemosensitizer in ovarian cancer therapy.

The heat source based on the self-propagation reaction of Al/Ni thin foil has the characteristics of concentrated heat, fast temperature rise/fall rate and small heat-affected zone; it can complete the melting and solidification crystallization of solder within milliseconds to realize solder interconnection, which can solve the problems of damage to heat-sensitive materials and components caused by monolithic heating of package structure. However, due to the highly non-stationary interconnection process, the resulting microstructure morphology may affect the service performance of the interconnected joints. In view of this, to investigate the post-solder microstructure of solder based on the self-propagation reaction, this paper analyzes the effect of the initial microstructure on the post-solder microstructure by heating 300-μm-thick SnBi solder with a 40-μm Al/Ni thin foil. The results indicated that the short melting time could resulted in the incomplete melting of heterogeneous phases and the non-uniform distribution of elements during the melting process, which had a significant effect on the morphology and composition distribution of the solidified microstructure, as well as the hardness distribution of the melted zone. The above conclusions have the potential to improve the interconnection process based on the self-propagation reaction, which is critical for both theoretical guidance and engineering application.