Starch, being one
of the most abundant polysaccharides in nature,
has been modified as starch-based thermoplastic materials for decades.
In this work, we have demonstrated a green and facile method for choline
phytate (CPA), which is not only a fire retardant but also a plasticizer
for starch. Thermoplastic starch (TPS) plasticized with glycerol,
CPA, and water was prepared by melt blending. The plasticizing effect
was investigated by crystallinity calculation and a tensile test.
Also, the flame retardancy of CPA for TPS films was evaluated by combustion
tests. As the CPA loading increased, the crystallinity of TPS films
decreased from 11.7% to 7.6%. With the addition of 30 phr CPA, the
TPS film could pass a UL-94 V-0 rating (1 mm) and the limiting oxygen
index was increased to 43.7%. Cone calorimeter characterization revealed
that the heat release of SGCPA
X
composites
was efficiently restrained by CPA. The peak of heat release rate was
decreased by 68.7% and total heat release was decreased by 33.8% for
the TPS films containing 20 phr CPA. The flame-retardant mechanism
of CPA in TPS played the key role by the analysis of the char residues.
We characterized the synergistic effect produced between pterostilbene and polymyxin B (fractional inhibitory concentration [FIC] index = 0.156 or 0.188) against MCR-producing strains of both human and animal origins. The time-killing assays showed that either pterostilbene or polymyxin B failed to eradicate the- and NDM-positive strain ZJ487, but the combination eliminated the strain by 1 h postinoculation. The survival rate of mice after intraperitoneal infections was significantly enhanced from 0% to 60% in the group in which combination therapy was applied.
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