Person Re-identification (re-id) faces two major challenges: the lack of cross-view paired training data and learning discriminative identity-sensitive and viewinvariant features in the presence of large pose variations. In this work, we address both problems by proposing a novel deep person image generation model for synthesizing realistic person images conditional on pose. The model is based on a generative adversarial network (GAN) designed specifically for pose normalization in re-id, thus termed pose-normalization GAN (PN-GAN). With the synthesized images, we can learn a new type of deep re-id feature free of the influence of pose variations. We show that this feature is strong on its own and complementary to features learned with the original images. Importantly, under the transfer learning setting, we show that our model generalizes well to any new re-id dataset without the need for collecting any training data for model fine-tuning. The model thus has the potential to make re-id model truly scalable.

SUMMARY The complex biochemical effects of RAF inhibitors account for both the effectiveness and mechanisms of resistance to these drugs, but a unified mechanistic model has been lacking. Here we show that RAF inhibitors exert their effects via two distinct allosteric mechanisms. Drug resistance due to dimerization is determined by the position of the αC-helix stabilized by inhibitor, whereas inhibitor-induced RAF priming and dimerization are the result of inhibitor-induced formation of the RAF/RAS-GTP complex. The biochemical effect of RAF inhibitor in cells is the combined outcome of the two mechanisms. Therapeutic strategies including αC-helix-IN inhibitors are more effective in multiple mutant BRAF-driven tumor models, including colorectal and thyroid BRAFV600E cancers, in which first generation RAF inhibitors have been ineffective.

In this paper, we strive to answer two questions: What is the current state of 3D hand pose estimation from depth images? And, what are the next challenges that need to be tackled? Following the successful Hands In the Million Challenge (HIM2017), we investigate the top 10 state-ofthe-art methods on three tasks: single frame 3D pose estimation, 3D hand tracking, and hand pose estimation during object interaction. We analyze the performance of different CNN structures with regard to hand shape, joint visibility, view point and articulation distributions. Our findings include: (1) isolated 3D hand pose estimation achieves low mean errors (10 mm) in the view point range of [70, 120] degrees, but it is far from being solved for extreme view points; (2) 3D volumetric representations outperform 2D CNNs, better capturing the spatial structure of the depth data; (3) Discriminative methods still generalize poorly to unseen hand shapes; (4) While joint occlusions pose a challenge for most methods, explicit modeling of structure constraints can significantly narrow the gap between errors on visible and occluded joints.

We introduce a shape detection framework called Contour Context Selection for detecting objects in cluttered images using only one exemplar. Shape based detection is invariant to changes of object appearance, and can reason with geometrical abstraction of the object. Our approach uses salient contours as integral tokens for shape matching. We seek a maximal, holistic matching of shapes, which checks shape features froma large spatial extent, as well as long-range contextual relationships among object parts. This amounts to finding the correct figure/ ground contour labeling, and optimal correspondences between control points on/around contours. This removes accidental alignments and does not hallucinate objects in background clutter, without negative training examples. We formulate this task as a set-to-set contour matching problem. Naive methods would require searching over 'exponentially' many figure/ground contour labelings. We simplify this task by encoding the shape descriptor algebraically in a linear form of contour figure/ground variables. This allows us to use the reliable optimization technique of Linear Programming. We demonstrate our approach on the challenging task of detecting bottles, swans and other objects in cluttered images. Abstract. We introduce a shape detection framework called Contour Context Selection for detecting objects in cluttered images using only one exemplar. Shape based detection is invariant to changes of object appearance, and can reason with geometrical abstraction of the object. Our approach uses salient contours as integral tokens for shape matching. We seek a maximal, holistic matching of shapes, which checks shape features from a large spatial extent, as well as long-range contextual relationships among object parts. This amounts to finding the correct figure/ground contour labeling, and optimal correspondences between control points on/around contours. This removes accidental alignments and does not hallucinate objects in background clutter, without negative training examples. We formulate this task as a set-to-set contour matching problem. Naive methods would require searching over 'exponentially' many figure/ground contour labelings. We simplify this task by encoding the shape descriptor algebraically in a linear form of contour figure/ground variables. This allows us to use the reliable optimization technique of Linear Programming. We demonstrate our approach on the challenging task of detecting bottles, swans and other objects in cluttered images.

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