Drug resistance is an obstacle in the chemotherapeutic treatment of lung cancers. In the present study, the effects of high-mobility group box 1 (HMGB1) protein in chemotherapeutic resistance and the relationships between HMGB1 and chemotherapy drug-induced cell apoptosis or necrosis were clarified. We used cisplatin-sensitive A549 cells and cisplatin-resistant A549/DDP cells as cell models with IC50 of 11.58 and 46.95 μM, respectively. A549/DDP had higher level of HMGB1 compared with A549 cells. Interestingly, with the increasing concentration of DDP, HMGB1 was gradually located into cytoplasm in cisplatin-sensitive A549 cells. Moreover, interference with endogenous HMGB1 sensitized the effects of chemotherapeutic drugs, including 5-Fu, DDP, and OXA. Furthermore, results from an in vivo tumorigenesis experiment demonstrated that serum concentration of HMGB1 was much lower in the group inoculated with HMGB1 shRNA-transfected A549 cells than in the N.C. shRNA-transfected A549 inoculated group, as well as the tumor volume, suggesting that serum HMGB1 contributed to tumor growth in a mouse model. In conclusion, higher levels of HMGB1 probably contributed to chemotherapy drug resistance, and higher serum concentration of HMGB1 promoted in vivo tumor growth. The study would provide new clues to overcome drug resistance in chemotherapy of human lung cancers.
A membrane bioreactor (MBR) with gravity drain was tested for domestic wastewater for 65 days. Results showed that the effluent quality was excellent, and met with the reuse water standard of China (GB/T 18920-2002). Virus removal in the membrane separation process was investigated by employing coliphages T4 as a tracer. Two microfiltration membrane modules, with pore sizes of 0.22 and 0.1 m, were used to investigate their effects on virus rejection at the transmembrane pressure of 8.5 kPa. It was found that 0.1 m membrane had complete rejection of virus, and 0.22 m membrane had significant rejection of virus. In the longterm operation of this MBR, no significant difference was observed between both pore sizes because the virus concentrations of the effluent in both cases were in the same order. Effluent virus concentration at steady state of MBR running was less than 2 PFU/mL. The removal ratios of coliphage T4 in MF processes were more than 10 5.5 . The membrane surface deposits played an important role in the rejection of virus. The formation of cake clay on the membrane surface was the main cause of high rejection of coliphage T4 with MF of 0.22 m.
In order to prevent possible charring, oxidation and (or) vaporisation of substances other than pore water, many researchers have adopted oven-drying temperature (t) values in the range 60–90°C for water content determinations of peat and other highly organic soils. This paper investigates the oven-drying characteristics of six very different highly decomposed peaty soils retrieved from south-west China for t values of 65, 85 and 105°C. Based on the presented experimental data, it is concluded that the standardised t value of 105°C used for testing of inorganic soil is also appropriate (and preferable to using lower t values) for routine water content determinations of these soils, which is in line with the growing consensus formed by other researchers on this topic. Further, the authors recommend a wet specimen mass of approximately 50 g and a 24 h oven-drying period in performing the oven-drying tests for t = 105°C. The paper also describes an existing approach to comparing and standardising water content values determined for the same organic soil, but on the basis of different t values, with the new data presented herein for the six Chinese soils used to strengthen its wider applicability in geotechnical engineering practice and related fields.
Customizability is a key feature of the Android operating system that differentiates it from Apple's iOS. One concrete feature that gaining popularity is called "app virtualization''. This feature allows multiple copies of the same app to be installed and opened simultaneously (e.g., with multiple accounts logged in). Virtualization frameworks are used by more than 100 million users worldwide. As with any new system features, we are interested in two aspects: (1) whether the feature itself introduces security risks and (2) whether the feature is abused for unintended purposes. This paper conducts a systematic study on the two aspects of the app virtualization techniques. With a thorough study of 32 popular virtualization frameworks from Google Play, we identify seven areas of potential attack vectors and find that most of the frameworks are susceptible to them. By deeply investigating their ecosystem, we show, with demonstrations, that attackers can easily distribute malware that takes advantage of these attack vectors. In addition, we show that the same virtualization techniques are also abused by malware as an alternative and easy-to-use repackaging mechanism. To this end, we design and implement a new app repackage detector. After scanning 250,145 apps from app markets, it finds 164 repackaged apps that attempt to steal user credentials and private data.
Peaty soils have an extremely high water content and a low specific gravity of solids (G s) compared with most inorganic soils. Accurate knowledge of the G s value allows void ratio computations for given water contents and densities. However, G s determinations using the standard pycnometer test are time consuming and pernickety, such that the G s value is often predicted by way of ignition loss (N) correlations instead. This paper presents original G s–N data for 25 peaty soils (N = 23–86%) from the Dian-Chi Lake area, Kunming City, China, along with a data set assembled from various sources in the literature for 77 peaty clays and peats. The main research aim is to investigate correlations between G s, natural water content (w n) and N for the standard ignition temperature of 440°C, thereby allowing indirect G s estimations. For the 102 peaty soils examined, the best-fit G s–N correlation was obtained for specific gravities of the inorganic and organic solids fraction values of 2.77 and 1.35, respectively. A weaker inverse bilinear relationship was found between G s and w n. To overcome procedural differences between codes and for previous experimental work, it is recommended that an oven temperature of 105°C be consistently used for drying peaty soil specimens.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
customersupport@researchsolutions.com
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.