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Laminin-modified thiolated gellan gum and loaded with the nerve growth factor in facilitateding neuronal stem cell proliferation and differentiation.

Bone transplantation has been used to repair bone defects for more than 300 years. Only in the United States, more than 1 million patients need bone grafting every year because of severe trauma, bone tumor, deformity and so on. Traditional bone graft materials include autogenous bone, allogeneic bone and artificial bone, but their wide application is limited because of various defects. With the development of biomedicine, tissue engineering and material science, the application of tissue engineered bone in the repair of bone defects has become a research hotspot.

The tibial plateau Schatzker type Ⅲ fracture is a simple lateral collapse fracture, which is mainly seen in the low energy injuries of the knee joint in older patients with osteoporosis. (1-3) The treatment options for this type of fracture are open reduction and internal fixation. Repairing the alignment of the collapsed joint surface and the tibial force line is the final goal of surgical treatment. Usually the choice of internal fixation is the combination of ship valve screw arrangement and support steel plate. (4)Many authors recommend avoiding the use of simple hollow screws, especially in comminuted fractures with more severe joint defects, as this can easily lead to secondary collapse of the joint.(5)The traditional surgical method is an anterior-lateral approach with open reduction and internal fixation. Due to the long incision, large trauma, and poor medical compliance of the elderly, it is prone to complicated knee stiffness and traumatic arthritis. The surgical effect is not satisfactory.

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