Introduction: Adverse drug reactions (ADRs) represent a public health problem worldwide that deserves attention due to the impact on mortality, morbidity, and healthcare costs. Drug–drug interactions (DDIs) are an important contributor to ADRs. Most of the studies focused only on potential DDIs (pDDIs), while the detailed data are limited regarding the ADRs associated with actual DDIs.Methods: This retrospective study evaluated ADRs reported between 2011 and 2020 in a tertiary hospital. The causality and severity of ADRs were evaluated through the Naranjo Algorithm and Hartwig’s scale, respectively. Preventability classification was based on the modified Schoumock and Thornton scale. For ADRs with at least two suspected drugs, pDDIs were identified according to the Lexi-Interact. We further checked whether the ADR description in the reports corresponded to the clinical consequences of the pDDIs.Results: A total of 1,803 ADRs were reported, of which 36.77% ADRs were classified as mild, 43.26% as moderate, and 19.97% as severe. The assessment of causality showed that the distributions of definite, probable, and possible categories were 0.33%, 58.68%, and 40.99%, respectively. A total of 53.97% of ADRs were identified as preventable ADRs, while 46.03% were recognized as unpreventable. The severity of ADRs was significantly correlated with age, the number of suspected drugs and preventability. Antimicrobial agents were the most common implicated pharmacological group, and the most frequently affected system was the gastrointestinal system. Considering individual drugs, aspirin was the most frequently reported drug. Among 573 ADRs with at least two suspected drugs, 105 ADRs were caused by actual DDIs, of which only 59 and 6 ADRs were caused by actual DDIs in category D and X, respectively. The most frequent drugs involved in actual DDIs of category D were aspirin and heparin, with the majority of ADRs being gastrointestinal bleeding.Conclusion: This study analyzed the pattern of ADRs in detail and obtained clinical evidence about ADRs associated with actual DDIs. These findings may be useful to compare patterns between different centers and to design preventive strategies for ADRs. Continuous education and training should be provided for physicians regarding the knowledge and recognition of ADRs associated with DDIs.

Background: Triethylamine is an important intermediate reactant and is widely used in industry and manufacturing. So far, cases of triethylamine poisoning timely saved are rarely reported.Methods: A 29-year-old male worker from a chemical plant after taking a small sip of triethylamine was presented in ICU. Subsequently, he experienced repeated vomiting, abdominal pain, gastrointestinal bleeding and other related injuries. Owing to no significant improvement in local hospital, he was transferred to Jinshan hospital, Fudan University for better medical treatment. He received hemostasis, PPIs for gastrointestinal mucosal recovery, blood purification for poison removal, nutritional and electrolyte supplement after admission. The author participates in treatment and analyzes clinical results in order to share treatment methods and experience for similar poisoning events in future.Results: His gastrointestinal bleeding was timely controlled, his pain and other poisoning symptoms were eliminated. And he was discharged home safely. Conclusions: Triethylamine can break the gastric mucosal barrier, the administration of proton pump inhibitors (PPIs) had a great importance. The timely blood purification for him helped eliminate the residual chemical poison inside his body, so his further liver injury by triethylamine was prevented. His recovery is good.