AbstrakRefluks laringofaring adalah aliran balik isi lambung ke daerah laringofaring dan dapat dipengaruhi oleh infeksi Helicobacter pylori. Regimen terapi untuk infeksi H. pylori terdiri atas proton pump inhibitor (PPI) dan dua jenis antibiotik yaitu amoksisilin dan klaritromisin. Peran PPI pada regimen ini masih diteliti. Dilakukan penelitian mengenai perbandingan efektivitas terapi antibiotik disertai PPI (lansoprazol) terhadap perbaikan gejala klinis dan kualitas hidup penderita refluks laringofaring dengan infeksi H. pylori. The Effectiveness of Antibiotics with Lansoprazole in the Treatment of Laryngopharyngeal Reflux with Helicobacter pylori Infection AbstractLaryngopharyngeal Reflux (LPR) is a reflux of gastric content to the laryngopharyngeal and influenced by Helicobacter pylori infection. The treatment of H. pylori infection consists of proton pump inhibitor and two kinds of antibiotics, i.e. amoxicillin and clarithromycin. The role of PPI is currently being studied. The objectives of the research were to compare the effectiveness of antibiotics regimen with and without lansoprazole in reducing the level of the severity and quality of life improvement in LPR patients with H. pylori infection. Twenty six subjects were divided into two groups; the first group received antibiotics with lansoprazole and the second group received antibiotics without lansoprazole. The research subjects were assessed using reflux symptom index (RSI) questionnaire and reflux finding score (RFS) while the assessment on the quality of life was performed using reflux qual short-form (RQS) questionnaire. These data were obtained at baseline and after 2 weeks of treatment. The method was randomized clinical trial with open label observation and the analysis was conducted using t and Mann Whitney tests. There was a significant improvement in the RSI post treatment in the first group (p=0.034). The difference in RFS was not significantly different statistically between both groups (p=0.169). The RQS was significantly better statistically in the first group (p=0.018). It is concluded that treatment regimen with claritromicin, amoxycillin and lansoprazole is more effective in the treatment of LPR associated with H. pylori infection compared to without lansoprazole. [MKB. 2012;44(4):224-32].

Acute coronary syndrome (ACS) is a syndrome consist of several coronary disease such as unstable angina pectoris (UAP), non-ST-elevation myocardial infarction (NSTEMI), and ST-elevation myocardial infarction (STEMI). ACS risk factors are devided into two main categories, the conventional risk factors and recently known atherothrombosisassociated risk factors. Hypertension is one of ACS major risk factors. This study aims to determine the Coherence of the stage of hypertension with the incidence of ACS in the CardiacInpatient Room Dustira Cimahi Hospital in 2018. This study was an analytical study with a cross-sectional method approach, the population in this study were all ACS patients that recorded in medical record, while the respondents were ACS patients with a history of hypertension recorded in medical record and treated at Dustira Cimahi Hospital with total 112 samples, by using systematic random sampling. Based on the research, there were 48 men patients (42.90%), while femen patients were 64 (57.10%). The average age of patients was 61.75 years old. Obtained from 19 people with normal-high blood pressure degree, 10 people (52.63%) were ACS-UAP, from 24 patients with first stage of hypertension as many as 15 people (62.50%) were ACS-UAP, from 29 patients with second stage of hypertension as many as 18 people (62.07%) were ACS NSTEMI, and from 40 patients with third stage of hypertension as many as 29 people (72.50%) were ACS STEMI. A p-value of 0.000 showed a significant Coherence between the stage of hypertension and the incidence of acute coronary syndrome at Dustira Hospital Cimahi in 2018.