No abstract

In the present paper, the delayed feedback control is applied to suppress or stabilize the vibration of the primary system in a two degree-of-freedom dynamical system with parametrically excited pendulum. The case of a 1 : 2 internal resonance between pendulum and primary system is studied. The method of multiple scales is applied to obtain second-order approximations of the response of the system. The system stability and bifurcations of equilibrium point of the averaged equations are computed. It is shown that the delayed feedback control can be used to suppress the vibration or stabilize the system when the saturation control is invalid. The vibration of the primary system can be suppressed by the delayed feedback control when the original system is in the single-mode motion. The effect of gain and delay on the vibration suppression is discussed. As the delay varies at a fixed value of the gain, the vibration of the primary system can be suppressed at some values of the delay. The vibration suppression performance of the system is improved at a large value of the gain. The vibration of the primary system could be suppressed about 56% compared with the original system by choosing the appropriate values of gain and delay. The delayed feedback control also can be used to stabilize the system when the original system is unstable. The gain and delay could be chosen as the controlling parameters. Numerical simulation is agreement with the analytical solutions well.

The radiochromic film (RCF) is a high-dose, high-dynamic range dosimetry detection medium. A stack of RCFs can be used to detect both spatial and energetic distribution of laser driven ion beams with a large divergence angle and continuous energy spectrum. Two types of RCFs (HD-V2 and MD-V3, from Radiation Products Design, Inc.) have been calibrated using MeV energy protons and carbon ions produced by using a 2 × 6 MV tandem electrostatic accelerator. The proportional relationship is obtained between the optical density and the irradiation dose. For protons, the responses are consistent at all energies with a variation of about 15%. For carbon ions, the responses are energy related, which should be noted for heavy ion detection. Based on the calibration, the broad energy spectrum and charge distribution of laser accelerated proton beam with energy from 3 to 8 MeV and pC charge were detected and reconstructed at the Compact LAser Plasma Accelerator at Peking University.

Cancer stem cell (CSC) is thought to be the major cause of radio-resistance and relapse post radiotherapy (RT). Recently ultra-high dose rate “FLASH-RT” evokes great interest for its decreasing normal tissue damages while maintaining tumor responses compared with conventional dose rate RT. However, the killing effect and mechanism of FLASH irradiation (FLASH-IR) on CSC and normal cancer cell are still unclear. Presently the radiation induced death profile of CSC and normal cancer cell were studied. Cells were irradiated with FLASH-IR (∼109 Gy/s) at the dose of 6–9 Gy via laser-accelerated nanosecond particles. Then the ratio of apoptosis, pyroptosis and necrosis were determined. The results showed that FLASH-IR can induce apoptosis, pyroptosis and necrosis in both CSC and normal cancer cell with different ratios. And CSC was more resistant to radiation than normal cancer cell under FLASH-IR. Further experiments tracing lysosome and autophagy showed that CSCs had higher levels of lysosome and autophagy. Taken together, our results suggested that the radio-resistance of CSC may associate with the increase of lysosome-mediated autophagy, and the decrease of apoptosis, necrosis and pyroptosis. To our limited knowledge, this is the first report shedding light on the killing effects and death pathways of CSC and normal cancer cell under FLASH-IR. By clarifying the death pathways of CSC and normal cancer cell under FLASH-IR, it may help us improve the understanding of the radio-resistance of CSC and thus help to optimize the future clinical FLASH treatment plan.

A compact laser plasma accelerator (CLAPA) that can stably produce and transport proton ions with different energies less than 10 MeV, <1% energy spread, several to tens of pC charge, is demonstrated. The high current proton beam with continuous energy spectrum and a large divergence angle is generated by using a high contrast laser and micron thickness targets, which later is collected, analyzed and refocused by an image-relaying beam line using a combination of quadrupole and bending electromagnets. It eliminates the inherent defects of the laser-driven beams, realizes precise manipulation of the proton beams with reliability, availability, maintainability and inspectability (RAMI), and takes the first step towards applications of this new generation of accelerator. With the development of high-rep rate Petawatt (PW) laser technology, we can now envision a new generation of accelerator for many applications in the near future soon.