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ThTÀ E (ethyl-substitutive Thioflavin T), a derivative of Thioflavin T (ThT), is capable of inducing a guanine -rich nucleic acid sequence that forms a parallel G-quadruplex under certain conditions and exhibits significant fluorescence enhancement. In this work, we used Pb 2 + to induce parallel G-quadruplex into anti-parallel G-quadruplex to reduce fluorescence of ThTÀ E and found a simple Pb 2 + detection method. Through this approach, Pb 2 + in aqueous solutions can be detected at 0. 76 nM with fluorescence spectrometry in a facile way, with high selectivity against other metal ions. These results indicate the method for detecting Pb 2 + is simple, sensitive, specific and label-free.

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