Glioma is the main type of malignant brain tumor in adults, and the status of isocitrate dehydrogenase (IDH) mutation highly affects the diagnosis, treatment, and prognosis of gliomas. Radiographic medical imaging provides a noninvasive platform for sampling both inter and intralesion heterogeneity of gliomas, and previous research has shown that the IDH genotype can be predicted from the fusion of multimodality radiology images. The features of medical images and IDH genotype are vital for medical treatment; however, it still lacks a multitask framework for the segmentation of the lesion areas of gliomas and the prediction of IDH genotype. In this paper, we propose a novel three-dimensional (3D) multitask deep learning model for segmentation and genotype prediction (SGPNet). The residual units are also introduced into the SGPNet that allows the output blocks to extract hierarchical features for different tasks and facilitate the information propagation. Our model reduces 26.6% classification error rates comparing with previous models on the datasets of Multimodal Brain Tumor Segmentation Challenge (BRATS) 2020 and The Cancer Genome Atlas (TCGA) gliomas’ databases. Furthermore, we first practically investigate the influence of lesion areas on the performance of IDH genotype prediction by setting different groups of learning targets. The experimental results indicate that the information of lesion areas is more important for the IDH genotype prediction. Our framework is effective and generalizable, which can serve as a highly automated tool to be applied in clinical decision making.

Support Vector Regression (SVR) and its variants are widely used regression algorithms, and they have demonstrated high generalization ability. This research proposes a new SVR-based regressor : v-minimum absolute deviation distribution regression (v-MADR) machine. Instead of merely minimizing structural risk, as with v-SVR, v-MADR aims to achieve better generalization performance by minimizing both the absolute regression deviation mean and the absolute regression deviation variance, which takes into account the positive and negative values of the regression deviation of sample points. For optimization, we propose a dual coordinate descent (DCD) algorithm for small sample problems, and we also propose an averaged stochastic gradient descent (ASGD) algorithm for large-scale problems. Furthermore, we study the statistical property of v-MADR that leads to a bound on the expectation of error. The experimental results on both artificial and real datasets indicate that our v-MADR has significant improvement in generalization performance with less training time compared to the widely used v-SVR, LS-SVR, ε-TSVR, and linear ε-SVR. Finally, we open source the code of v-MADR at https://github.com/AsunaYY/v-MADR for wider dissemination. INDEX TERMS v-support vector regression, absolute regression deviation mean, absolute regression deviation variance, dual coordinate descent algorithm.