Mesoporous silica nanoparticles (MSNs) are attracting increasing interest for potential biomedical applications. With tailored mesoporous structure, huge surface area and pore volume, selective surface functionality, as well as morphology control, MSNs exhibit high loading capacity for therapeutic agents and controlled release properties if modified with stimuli-responsive groups, polymers or proteins. In this review article, the applications of MSNs in pharmaceutics to improve drug bioavailability, reduce drug toxicity, and deliver with cellular targetability are summarized. Particularly, the exciting progress in the development of MSNs-based effective delivery systems for poorly soluble drugs, anticancer agents, and therapeutic genes are highlighted.

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We present DeepICP -a novel end-to-end learningbased 3D point cloud registration framework that achieves comparable registration accuracy to prior state-of-the-art geometric methods. Different from other keypoint based methods where a RANSAC procedure is usually needed, we implement the use of various deep neural network structures to establish an end-to-end trainable network. Our keypoint detector is trained through this end-to-end structure and enables the system to avoid the inference of dynamic objects, leverages the help of sufficiently salient features on stationary objects, and as a result, achieves high robustness. Rather than searching the corresponding points among existing points, the key contribution is that we innovatively generate them based on learned matching probabilities among a group of candidates, which can boost the registration accuracy. Our loss function incorporates both the local similarity and the global geometric constraints to ensure all above network designs can converge towards the right direction. We comprehensively validate the effectiveness of our approach using both the KITTI dataset and the Apollo-SouthBay dataset. Results demonstrate that our method achieves comparable or better performance than the state-of-the-art geometry-based methods. Detailed ablation and visualization analysis are included to further illustrate the behavior and insights of our network. The low registration error and high robustness of our method makes it attractive for substantial applications relying on the point cloud registration task.

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We present a robust and precise localization system that achieves centimeter-level localization accuracy in disparate city scenes. Our system adaptively uses information from complementary sensors such as GNSS, LiDAR, and IMU to achieve high localization accuracy and resilience in challenging scenes, such as urban downtown, highways, and tunnels. Rather than relying only on LiDAR intensity or 3D geometry, we make innovative use of LiDAR intensity and altitude cues to significantly improve localization system accuracy and robustness. Our GNSS RTK module utilizes the help of the multi-sensor fusion framework and achieves a better ambiguity resolution success rate. An error-state Kalman filter is applied to fuse the localization measurements from different sources with novel uncertainty estimation. We validate, in detail, the effectiveness of our approaches, achieving 5-10cm RMS accuracy and outperforming previous state-of-the-art systems. Importantly, our system, while deployed in a large autonomous driving fleet, made our vehicles fully autonomous in crowded city streets despite road construction that occurred from time to time. A dataset including more than 60 km real traffic driving in various urban roads is used to comprehensively test our system.