Digital core simulation technology, as an emerging numerical simulation method, has gradually come to play a significant role in the study of petrophysical properties. By using this numerical simulation method, the influence of micro factors on seepage properties of reservoir rock is taken into consideration, making up the shortcomings of the traditional physical experiment. Three-dimensional core images are reconstructed by a computed tomography scanning technique. Different sizes of the sub-region were simulated by three methods including the direct computation of Navier-Stokes equations, the simulation of the pore network model, and the lattice Boltzmann method. The permeability computed by each simulation was compared. After comparison between these three methods, the results of the direct computation method based on Navier-Stokes equations were found to be higher than the other two methods. The pore network model simulation has an obvious advantage on the computation speed and the simulation area. The lattice Boltzmann method shows the low efficiency due to the time-consuming process. At last, the permeability calculated by the three methods is matched by the Kozeny-Carman equation. A more accurate formula can be obtained by a series of numerical simulations, which can be applied to marco-scale simulation.

Water flooding is an economic method commonly used in secondary recovery, but a large quantity of crude oil is still trapped in reservoirs after water flooding. A deep understanding of the distribution of residual oil is essential for the subsequent development of water flooding. In this study, a pore-scale model is developed to study the formation process and distribution characteristics of residual oil. The Navier–Stokes equation coupled with a phase field method is employed to describe the flooding process and track the interface of fluids. The results show a significant difference in residual oil distribution at different wetting conditions. The difference is also reflected in the oil recovery and water cut curves. Much more oil is displaced in water-wet porous media than oil-wet porous media after water breakthrough. Furthermore, enhanced oil recovery (EOR) mechanisms of both surfactant and polymer flooding are studied, and the effect of operation times for different EOR methods are analyzed. The surfactant flooding not only improves oil displacement efficiency, but also increases microscale sweep efficiency by reducing the entry pressure of micropores. Polymer weakens the effect of capillary force by increasing the viscous force, which leads to an improvement in sweep efficiency. The injection time of the surfactant has an important impact on the field development due to the formation of predominant pathway, but the EOR effect of polymer flooding does not have a similar correlation with the operation times. Results from this study can provide theoretical guidance for the appropriate design of EOR methods such as the application of surfactant and polymer flooding.

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Continuous antisolvent crystallization of Dolutegravir Sodium was studied using a novel device integrating the microfluidic continuous crystallizer and the agitated crystallizer. This study successfully minimized the risks of channel blockage during continuous crystallization by innovating an approach to isolate crystal nucleation from subsequent crystal growth. We systematically investigated the effects of the antisolvent content, channel width, and stirring speed on the particle size, the crystal size distribution (CSD), and the morphology of the crystals. By optimization of experimental parameters, crystals can be continuously obtained with small particle sizes (D 50 values of 5−10 μm), narrow CSDs (widths of 4−7 μm), and prismatic morphologies by this apparatus and approach. The particle sizes D 50 and CSDs of crystals are reduced by 30% and 60% at least, respectively, compared with values of the commercial sample. Small and uniform crystals are particularly desirable in the pharmaceutical industry, which can significantly improve drug solubility, bioavailability, corresponding pharmacokinetic performance, and the properties of the tablet.