Both basal ganglia (BG) and orbitofrontal cortex (OFC) have been widely implicated in social and non-social decision-making. However, unlike OFC damage, BG pathology is not typically associated with disturbances in social functioning. Here we studied the behavior of patients with focal lesions to either BG or OFC in a multi-strategy competitive game known to engage these regions. We find that whereas OFC patients are significantly impaired, BG patients show intact learning in the economic game. By contrast, when information about the strategic context is absent, both cohorts are significantly impaired. Computational modeling further shows a preserved ability in BG patients to learn by anticipating and responding to the behavior of others using the strategic context. These results suggest that apparently divergent findings on BG contribution to social decision-making may instead reflect a model where higher-order learning processes are dissociable from trial-and-error learning, and can be preserved despite BG damage.

Strategic interactions, where an individual's payoff depends on the decisions of multiple intelligent agents, are ubiquitous among social animals. They span a variety of important social behaviors such as competition, cooperation, coordination, and communication, and often involve complex, intertwining cognitive operations ranging from basic reward processing to higher‐order mentalization. Here, we review the progress and challenges in probing the neural and cognitive mechanisms of strategic behavior of interacting individuals, drawing an analogy to recent developments in studies of reward‐seeking behavior, in particular, how research focuses in the field of strategic behavior have been expanded from adaptive behavior based on trial‐and‐error to flexible decisions based on limited prior experience. We highlight two important research questions in the field of strategic behavior: (i) How does the brain exploit past experience for learning to behave strategically? and (ii) How does the brain decide what to do in novel strategic situations in the absence of direct experience? For the former, we discuss the utility of learning models that have effectively connected various types of neural data with strategic learning behavior and helped elucidate the interplay among multiple learning processes. For the latter, we review the recent evidence and propose a neural generative mechanism by which the brain makes novel strategic choices through simulating others' goal‐directed actions according to rational or bounded‐rational principles obtained through indirect social knowledge. This article is categorized under: Economics > Interactive Decision‐Making Psychology > Reasoning and Decision Making Neuroscience > Cognition