Virtual reality (VR) over wireless is emerging as an important use case of 5G networks. Immersive VR experience requires the delivery of huge data at ultra-low latency, thus demanding ultra-high transmission rate. This challenge can be largely addressed by the recent network architecture known as mobile edge computing (MEC), which enables caching and computing capabilities at the edge of wireless networks. This paper presents a novel MEC-based mobile VR delivery framework that is able to cache parts of the field of views (FOVs) in advance and run certain post-processing procedures at the mobile VR device. To optimize resource allocation at the mobile VR device, we formulate a joint caching and computing decision problem to minimize the average required transmission rate while meeting a given latency constraint. When FOVs are homogeneous, we obtain a closed-form expression for the optimal joint policy which reveals interesting communicationscaching-computing tradeoffs. When FOVs are heterogeneous, we obtain a local optima of the problem by transforming it into a linearly constrained indefinite quadratic problem then applying concave convex procedure. Numerical results demonstrate great promises of the proposed mobile VR delivery framework in saving communication bandwidth while meeting low latency requirement.

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Systemic inflammation responses have been associated with cancer development and progression. C-reactive protein (CRP), Glasgow prognostic score (GPS), neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), lymphocyte-monocyte ratio (LMR), and neutrophil-platelet score (NPS) have been shown to be independent risk factors in various types of malignant tumors. This retrospective analysis of 162 osteosarcoma cases was performed to estimate their predictive value of survival in osteosarcoma. All statistical analyses were performed by SPSS statistical software. Receiver operating characteristic (ROC) analysis was generated to set optimal thresholds; area under the curve (AUC) was used to show the discriminatory abilities of inflammation-based scores; Kaplan-Meier analysis was performed to plot the survival curve; cox regression models were employed to determine the independent prognostic factors. The optimal cut-off points of NLR, PLR, and LMR were 2.57, 123.5 and 4.73, respectively. GPS and NLR had a markedly larger AUC than CRP, PLR and LMR. High levels of CRP, GPS, NLR, PLR, and low level of LMR were significantly associated with adverse prognosis (P < 0.05). Multivariate Cox regression analyses revealed that GPS, NLR, and occurrence of metastasis were top risk factors associated with death of osteosarcoma patients.

Mobile virtual reality (VR) delivery is gaining increasing attention from both industry and academia due to its ability to provide an immersive experience. However, achieving mobile VR delivery requires ultra-high transmission rate, deemed as a first killer application for 5G wireless networks. In this paper, in order to alleviate the traffic burden over wireless networks, we develop an implementation framework for mobile VR delivery by utilizing caching and computing capabilities of mobile VR device. We then jointly optimize the caching and computation offloading policy for minimizing the required average transmission rate under the latency and local average energy consumption constraints. In a symmetric scenario, we obtain the optimal joint policy and the closed-form expression of the minimum average transmission rate. Accordingly, we analyze the tradeoff among communication, computing and caching, and then reveal analytically the fact that the communication overhead can be traded by the computing and caching capabilities of mobile VR device, and also what conditions must be met for it to happen. Finally, we discuss the optimization problem in a heterogeneous scenario, and propose an efficient suboptimal algorithm with low computation complexity, which is shown to achieve good performance in the numerical results.