The aim of this study was to investigate the correlation of the proinflammatory marker tumor necrosis factor-α (TNF-α) and the tubular marker neutrophil gelatinase-associated lipocalin (NGAL) with the progression of the early stage of type 2 diabetic nephropathy (DN). Baseline levels of urinary TNF-α and NGAL were measured in 63 non-diabetic controls and 201 patients with type 2 diabetes and different albuminuria statuses. The patients with diabetes (n=125) with normo- or microalbuminuria were subsequently followed-up for 28 (25–32) months, with routine measurements of creatinine and urinary albumin excretion (UAE). It was observed that baseline levels of urinary TNF-α and NGAL were significantly elevated and correlated with the severity of albuminuria in patients with diabetes. During the follow-up, the urinary levels of TNF-α and NGAL were observed to be significantly correlated with a rapid decline in the estimated glomerular filtration rate (eGFR). Following adjustment for other progression promoters, including albuminuria, TNF-α remained a significant predictor of eGFR decline. These results suggest that inflammation is important in the pathogenesis of DN and indicate that TNF-α may be used as an independent predictor for the progression of DN at the early stage.

In this paper, we propose a novel approach to two-view minimal-case relative pose problems based on homography with a common reference direction. We explore the rank-1 constraint on the difference between the Euclidean homography matrix and the corresponding rotation, and propose an efficient two-step solution for solving both the calibrated and partially calibrated (unknown focal length) problems. We derive new 3.5-point, 3.5-point, 4-point solvers for two cameras such that the two focal lengths are unknown but equal, one of them is unknown, and both are unknown and possibly different, respectively. We present detailed analyses and comparisons with existing 6-and 7-point solvers, including results with smart phone images

No abstract

No abstract

No abstract