The antiulcer activity of a hydro-ethanolic extract prepared from the stems of Kielmeyera coriacea Mart. (Guttiferae) was evaluated in rats employing the ethanol-acid, acute stress and Indomethacin models to induce experimental gastric ulcers. Treatment with K coriacea hydro-ethanolic extract provided significant antiulcer protection in the ethanol-acid and Indomethacin models, but not in the acute stress model. These results suggested that the K coriacea hydro-ethanolic extract increased resistance to necrotizing agents, providing a direct, protective effect on the gastric mucosa.
A atividade antiulcerogênica do extrato hidroetanólico de caule de Kielmeyera coriacea Mart. (Guttiferae) foi avaliada em ratos por meio de três modelos experimentais: etanol-ácido, indometacina e estresse agudo. O índice ulcerativo observado após o tratamento com o extrato de Kielmeyera coriacea foi comparado com a droga de referência, cimetidina. O tratamento com o extrato mostrou significante atividade anti-ulcerogênica nos modelos de indução de lesões de mucosa gástrica produzidas por etanol-ácido e indometacina, mas não contra úlcera induzida pelo modelo de estresse agudo. Etanol-ácido e agentes antiinflamatórios, como a indometacina, são compostos que produzem úlcera de mucosa gástrica. Os resultados deste estudo sugerem uma atividade protetora de mucosa gástrica para o extrato de Kielmeyera coriace

The stems of Kielmeyera coriacea Mart. (Clusiaceae) (syn. ''pau-santo'') are a therapeutic herbal in Brazilian folk medicine. This study investigates the effects of a hydroethanoli extract (HE) from Kielmeyera coriacea stems on the central nervous system (CNS) of rats. Chronic administration by gavage of the extract (60.0 mg=kg) revealed decreased immobility time in the forced swimming test (FST). This effect of the extract was compared with chronic treatment by gavage of fluoxetine (10.0 mg=kg) and nortriptyline (15.0 mg=kg). The antiimmobility effect of the HE from Kielmeyera coriacea in the FST was also investiged in association with the intra-dorsal raphe nucleus microinjection of 5-hydroxytryptamine (serotonin; 5-HT) or R(þ)-8-hydroxyl-2-(di-n-propylamino)tetralin (8-OHDPAT), a 5-HT 1A specific agonist receptor. The ligands, 5-HT (5.0 nmol) and 8-OHDPAT (0.6 and 1.0 nmol), significantly increased immobility time per se and blocked the anti-immobility effect of the extract. Biochemical investigations employing an in vitro synaptosomal assay showed uptake inhibition by the extract of [ 3 H]5-HT, [ 3 H]noradrenaline (NA), and [ 3 H]dopamine (DA) in the rat brain. These results suggest that serotonergic neurotransmission is involved in the antidepressant-like activity of the extract, as shown by the interaction with microinjected 5-HT and 8-OHDPAT, and that 5-HT, NA, and DA uptake inhibition may contribute to this effect.