In the present study, the nephroprotective potentials of cinnamon and/or parsley oils was assessed on gentamicin (GM)-induced nephrotoxicity in rats. About 49 male rats were assigned randomly into 7 equal groups (7 rats each). Group 1-3: were orally administered normal saline, cinnamon oil (400 mg kgG 1 b.wt.) and parsley oil (200 mg kgG 1 b.wt.), respectively, once daily for 30 consecutive days. Group 4: rats in this group were intraperitoneally injected with GM (100 mg kgG 1 b.wt.) in the last 10 days (20-30 th day) of the experiment. Group 5: rats in this group were given cinnamon and GM while rats in group 6 were administered parsley and GM. Group 7: rats in this group were administered cinnamon and parsley plus GM. At the end of the experiment, rats were sacrificed, serum samples and kidney specimens were collected for biochemical and oxidative status evaluation. Rats administered GM alone showed significant increases in serum concentrations of creatinine, urea and glucose while renal tissue levels of superoxide dismutase, catalase and glutathione reductase were significantly declined. Additionally, the malondialdehyde level was significantly elevated in kidney tissues. Also, GM administration caused renal histopathological alterations. The altered levels of various parameters provoked by GM toxicity were restored towards normal levels by cinnamon and/or parsley oils administration. These results suggested the nephroprotective potentials of cinnamon and/or parsley oils in rats, probably triggered by their antioxidant phytoconstituents.

This study was carried out to evaluate the efficacy of diclazuril in control of experimental Eimeria tenella infection in broiler chickens. The trial was carried out on 75, day-old broiler chicks as they were divided into 3 main equal separate groups (25 chicks; each). Group (1) was non infected non treated (control positive), group (2) was infected non treated (control negative) and group (3) was infected and treated with diclazuril. Groups (2 & 3) were orally received 1ml of an inoculum containing 100.000 sporulated oocysts of Eimeria tenella/ chick at 14 days of age. Chickens of group (3) were infected and rations were supplemented with diclazuril from 1 st day of experiment till the end of experiment (42 nd day). This study was assessed by effect of diclazuril on the performance parameters including feed intake, body weight (BW), body weight gain (BWG), feed conversion ratio, feed efficiency ratio and also mortalities in infected and treated chickens. Also, oocyst count (shedding) in the dropping and lesion score was also recorded. The results revealed that group treated with diclazuril showed great and significant improvement in (BW), (BWG) and (RGR) and also revealed the highest reduction in mortalities, lowered number of oocysts and the lesion score, indicating that diclazuril is an effective anticcocidial drug in treatment of E. tenella infection in chickens. Group provided with diclazuril gave significant and satisfactory improvement in the assessment criteria when compared with infected non treated group.