The epidemiological and clinicopathological features of canine mammary tumors may provide valuable information to facilitate analysis of the behavior of the disease and represent a potential tool for the study of breast cancer in women. The aim of this study was to associate the histological features of canine mammary tumors with potential risk factors and survival. One hundred and seventy-eight mammary tumors were collected from 80 female dogs. The statistical analyses consisted of a series of univariate studies and frequencies of the different study variables, such as a bivariate analysis with the Chi squared test (χ2), a relative risk and Kaplan Meier survival analysis, and a multiple correspondence analysis was used to correlate the tumor’s biological behavior with the dogs’ breed. Most patients were older than 8 years and had at least one malignant tumor, which was usually solitary and measured more than 6 cm; these patients had poor survival. The most frequent tumors were a complex adenoma, benign mixed tumor, carcinoma complex and mixed type carcinoma. The most commonly affected breeds were Poodle, Cocker Spaniel and Dachshund, and the breeds at the highest risk of tumor development were Cocker Spaniel, Labrador Retriever and German Shepherd. Overall, the data indicated that mammary tumors in dogs mainly affected older females with malignant tumors and that there were high mortality and short-term survival rates. However, the most commonly affected breeds were not necessarily the most susceptible. Our data do not support the hypothesis of an increased risk of canine mammary tumors in nulliparous female dogs.
Información y declaraciones adicionales en la página 11 Derechos de autor: Yaritza Salas et al. 2016 acceso abierto Distribuido bajo una Licencia Creative Commons Atribución 4.0 Internacional (CC-BY 4.0) Resumen Las características epidemiológicas y clínico-patológicas del tumor mamario canino es información valiosa para analizar el comportamiento de la enfermedad y son un recurso potencial para promover avances en el cáncer de mama en mujeres. El objetivo de este trabajo fue asociar las características histológicas del tumor mamario canino con factores potenciales de riesgo y el tiempo de sobrevida. De 80 perras enteras, se recolectaron 178 tumores mamarios. El análisis estadístico consistió en análisis de frecuencia de las variables de estudio, análisis bivariado con Chi cuadrado (χ 2), riesgo relativo, análisis de supervivencia Kaplan-Meier y un análisis de correspondencia múltiple que se utilizó para correlacionar el comportamiento biológico del tumor con la raza de las perras. La mayoría de las pacientes fueron mayores de 8 años de edad, con al menos un tumor maligno, casi siempre solitario, de gran tamaño y de mal pronóstico. Los tumores más frecuentes fueron el adenoma complejo, el tumor mixto benigno, el carcinoma complejo y el carcinoma tipo mixto. Las razas afectadas con mayor frecuencia fueron el Poodle, Cocker Spaniel y Dachshund; sólo el Cocker, el Labrador y el Pastor Alemán mostraron mayor riesgo. En general, los datos indican que el tumor mamario canino afecta sobre todo a hembras enteras, adultas mayores de 8 años de diversas razas; cursa con mortalidad alta y sobrevida corta en pacientes con tumor maligno de gran tamaño; sin embargo, las razas más afectadas no necesariamente son las más predispuestas. Este estudio no corrobora que exista un mayor riesgo de tumor mamario canino en perras nulíparas.
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