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Purpose: Apocrine adenocarcinoma is a cutaneous adnexal malignancy which can rarely arise from ocular structures. In this retrospective study, we report our experience with four patients who had primary periocular apocrine adenocarcinoma initially presenting with an orbital tumor. Methods: Data extracted included demographics, clinical, imaging, and histopathological features, and treatment outcomes. Results: The definitive diagnosis was established after an incisional biopsy in all cases. Two patients were then managed with exenteration. The third patient underwent local resection followed by radiotherapy but had to be exenterated because of new tumor formation 7 years later. The fourth patient had to be managed with oral bicalutamide which kept the tumor stable for 3 years. Recurrence-free survival for the radical surgical treatment group was 10, 6, and 7 years respectively. Conclusion: Periocular apocrine adenocarcinoma may insidiously develop as an orbital mass without any clinically detectable primary eyelid skin or conjunctival lesions. This tumor must be in the differential diagnosis of medially located ill-defined orbital masses in patients over 50 years of age. Orbital exenteration appeared as an effective treatment of apocrine adenocarcinoma with orbital extension. Anti-androgenic treatment in an androgen receptor-positive tumor provided temporary local tumor control.

Objective: To compare the electron microscopic lens findings with and without pseudoexfoliation syndrome (XFS), in patients undergoing surgery for senile cataract.

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Purpose: Our aim in this study is to report the clinical features and treatment results of patients with conjunctival melanoma (CM) diagnosed in our clinic in the last 20 years. Materials and Methods: Demographic information, tumor diameter, accompanying melanosis, presence of recurrence and survival data were obtained retrospectively from the records of patients who had histopathologically confirmed CM diagnosis. Results: Conjunctival melanoma was detected in 84 eyes of 84 patients with a mean age of 61.5±24.6 years. In total 45.2% of the patients were female and 54.8% were male. The two most common primary lesion locations were limbus in 23.8% and bulbar conjunctiva in 22.6% of the patients. In ophthalmological evaluation, 46.3% of the patients had concomitant primary acquired melanosis. Appropriate surgical excision to the extent of the disease was performed primarily in all patients. After a median follow-up of 55 months, local recurrence rate was 45.2%, while the survival rate was found to be 74.3%. Conclusion: Conjunctival melanoma is a malignant neoplasm seen in advanced adulthood, often involving the bulbar surface of the conjunctiva. Even using the standard surgical approach, CM is associated with a 45.2% local recurrence rate and a 25.7% mortality rate. In our study, there was no clinical parameter that showed a statistically significant relationship with survival.