No abstract

There was a modest correlation between length of ileal resection and severity of BAM as defined by 75SeHCAT retention values. Response to bile salt sequestrant therapy was not dependent on 75SeHCAT retention values.

Three glass compositions, one corresponding to fl-Eucryptite, another corresponding to Lithium Metasilicate and the third corresponding to 1070°C eutectic on the lithium metasilicate-fl-eucryptite join in the composition triangle lithium metasilicate -fl-spodumene-fl-eucryptite of the system Li 2 0-Al 2 0 3 -Si0 2 were studied with respect to their crystallization behaviour. The phases crystallizing out after different heat treatment schedules and itsing different nucleating agents were identified by X-ray diffraction patterns. In all cases, the initial crystallization product was Eucryptite silica-0 form. However, in the case of 1070°C eutectic composition the development of lithium metasi/icate phase was also noticed after heat treating at 800°C for 5 hours.The first DT A peak due to crystallization was used to distinguish the effects of Zr0 2 , Ti0 2 and V 2 0 5 as nucleating agents. With 5% zirconia additions the first crystallization peak temperature was maximum while in the case of 5% V 2 0 5 additions it was minimum. There was, however, no change in the initial crystallization products with and without the nucleating agents.

exocytosis; cytokine production and cellular response to cytokine stimulus. DSP analysis provided additional spatial transcriptomic data, highlighting differential inflammatory signature expression between the tumour and tumour capsule. Conclusion Our results demonstrate that the phenotype of tumour endothelium contributes to pathways which promote immune privilege in HCC. Spatial transcriptomics can provide further insight of how endothelial profiling correlates with immune cell infiltration in HCC. We have identified several new genes which need further validation but could be novel therapeutic targets that reprogramme the tumour endothelium and boost the efficacy of current immunotherapies.