Umbelliferon, the natural crenelated coumarin distributed in the plants of a piaceae family, has shown various biological activities, especially as a cancer chemo preventive agent. Coumarins have been categorized as a member of family of benzo-pyrone, that consist of pyrone ring united to benzene ring. The benzo-pyrones may be sectioned to alfa type that coumarins belong and the gama type that flavonoids have been major members. Coumarins are chemical entity which has being synthesized in the past few years many forms of its derivatives; the entity provides the principal origin of motivating to numerous chemist to investigate its diverse medical efforts especially with regards to the anticoagulant activity. In present article we review recent 4-Methylumbelliferon, (4-MU) that are synthesized with it pharmacological activities antioxidant, anti-inflammatory, antimicrobial activity, ant hepatitis, hepatoprotective, anticancer, antipyretic and analgesic activity.

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