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Background: Along with decreased sympatho-adrenal flow, catestatin has a number of cardiovascular effects. Reduced plasma catestatin levels could be a sign of a predisposition to develop metabolic and hypertensive diseases. Aim and objectives: To assess the function of catestatin in cardiometabolic risk assessment among diabetic children. Subjects and methods: This case-control study was carried out on 108 children at Pediatrics Department, Zagazig University Hospital. Children were divided into 2 groups: (Group A): Case group 54 children with diabetes, (Group B): Control group 54 apparent healthy children at same sex and age. Every infant was subjected to serum catestatin concentrations measurement using ELISA Kit. Result: Median Catestatin in diabetic group was 8.35 ng/ml (6.16 -17.41) while that for Control group was 11.19 ng/dl(7.42 -16.56), the difference was statistically significant (p< 0.05). Conclusion: Serum Catestatin was related to diabetes and it cannot be considered as a good biomarker of cardio metabolic risk among diabetic children. Further larger scale studies are needed to confirm our results.