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Abstract:Introduction: Rapid accumulation and toxicity can be developed if drugs dosages are not adjusted in patients with chronic kidney diseases (CKD). Objectives: To evaluate the prevalence of correct dosing in chronic kidney diseases depending on renal function estimation. Study Design: A cross-sectional observational study involving patients in medical ward from January to July 2014 at Aseer Central Hospital in Abha, Kingdom of Saudi Arabia Methods: Demographic data were collected from patients, patients' files and healthcare providers. Dosage adjustment depends on the patients' kidney function, most often estimated by the patient's glomerular filtration rate (eGFR) calculated by the CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration) and a computerized system was used to determine the adjusted renal dose. Results: From total 2470 prescribed drugs for 362 inpatients, 420 (17%) drugs need a dosing adjustment in chronic renal failure and 2050 (83%) drugs do not need. From the 420 drugs that need a dosing adjustment, the dose of 202 (48.1%) drugs were adjusted, and of 218 (51.9%) drugs were not. Drugs that need a readjustment are allopurinol, ampicillin, cefepime, cefixime, ceftazidime, ceftriaxone, gentamicin, levofloxacin, meropenem, metoclopramide, metronidazole, ranitidine, rosuvastatin, tazocin, tienam and vancomycin. Conclusions: The dosing of more than half of the medications that need dosing adjustment in CKD were not adjusted which can increase the side effects and toxicity of these drugs for CKD patients. It is the pharmacist duty by co-operation with the medical team to ensure the prescribing of optimal dose. Keywords: Aseer Central Hospital, Chronic kidney disease, chronic renal failure, CrCl, glomerular filtration rate, dialysis, dosing adjustment, Renal dysfunction, Renal impairment. Impact on practice-More focusing on prescribing is needed for drugs dose adjustment in patients with CKD. -Antibiotics constitute the majority of medications that need dosing adjustment in CKD. -Using computerized renal dosage adjustment program by pharmacists, clinicians, and general physician will result in appropriate drugs dosage and decrease the chance of adverse drug reactions and hospitalization rate and cost. -The study gives a flashlight on the importance of the collaboration among the medical team to improve the patients' outcome and quality of life.

Background Learning medication tradenames is a memorization challenge for pharmacy & healthcare students. Foundational courses utilize generic names. Nevertheless, experiential training followed by real‐life practice heavily utilize tradenames. Healthcare curricula are lacking in supporting such need. Decoding medication tradenames can help students to establish the connection between basic science concepts & corresponding clinical applications. For ex: Macrobid®; provides an elegant explanation of the (MACRO) size crystal form of (Macrodantin) designed for slower absorption & less excretion, hence, used twice daily (BID). Hypothesis Therefore, we hypothesized that decoding the hidden messages in tradenames (i.e: explanation of the methodologies &/or techniques used in formulating the top 200 medication tradenames in USA), can result in improved pharmacy students’ academic performance, self‐perception of competency & quality of learning in both Introductory Pharmacy Practice Experience (IPPE) didactic & experiential rotation courses. Methods An educational intervention of decoding medication tradenames was implemented in the form of Quizlet gimmicks & summary tables before the final summative exam in a didactic IPPE course for first year Pharmacy Students. Aggregate & de‐identified students’ scores were used for a blinded paired statistical analysis. A likert scale was used for evaluating the students’ self‐perception of competency & quality of learning experience using anonymous voluntary surveys of participating students after both the IPPE didactic and experiential rotation courses. Results In Fall 2018, prior to implementing the educational intervention, paired t‐test & Wilcoxon test for paired data analyses showed a statistically significant decrease in students’ performance in summative versus formative assessments (15.4% decrease, [95% CI: ‐12% to ‐18.6%], p‐value <0.001). Whereas, in Fall 2019 there was a statistically significant increase in students’ performance in summative versus formative assessments (7% increase, [95% CI: 4.4% to 9.7%], p‐value <0.001) after implementation of the education intervention. In parallel, at least 80% of students who responded to the survey questions reported that decoding medication tradenames helped them to retain the key features of the medications & connect it to their generic names during the IPPE didactic course. In addition, students also reported that it can help them to provide better medication recommendations, patient counseling sessions & make less medication errors after their experiential rotation course (n=72 / 94 students). Conclusions Supplementing pharmacy curricula with the art & science used in formulating the Top 200 medication tradenames can improve students’ academic performance & positive learning outcomes in didactic courses. Furthermore, decoding the hidden messages instrumented in medication tradenames can also help to improve future pharmacists’ self‐perception of confidence in their knowledge base and the resulting quality of healthcare servic...

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recommendations; (iii) at the dissemination stage, we carry out the analyses, report results on the website and to study authors and journal editors, as well as deposit prespecified files at a public repository (OSF). Results We completed a census to characterize the types of studies published in 2018 by the nine-journal cohort in exercise sciences. From a total of 3,205 individual references, we respectively classified 277 (9%; min-max range, 5 to 92) and 248 (8%; min-max range, 6 to 72) articles as RCTs and SRMAs. Currently, our three-stage process is ongoing and, from the two first months of surveillance, 38 RCTs and 27 SRMAs were eligible for analysis. We consolidated a comprehensive assessment using items from CONSORT 2010 and TIDieR checklist to appraise RCTs and from PRISMA, AMSTAR-2, and ROBIS to appraise SRMAs. In addition to full study reports with our assessment for all items, we proposed aggregated results using seven components (aggregating from 4 to 11 assessed items) that relate to: transparency, completeness, methodological rigor, participants, interventions/ exposures, outcome, and critical appraisal. Conclusions Inspired by the Mertonian principles and Doug Altman's wisdom, the SEES Initiative is a living, scalable, open project to promote adequate reporting, feedback stakeholders toward increased research uptake, and disrupt/denounce inadequate practices whenever necessary.