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Review question / Objective: Is dupilumab effective for treatment of children and adolescentes with moderate to severe atopic dermatitis? Does it improve SCORAD outomes? Does it reduce pruritus? Does it improve quality of life? Does improve sleep quality? Condition being studied: Atopic dermatitis is a common and chronic skin disease characerized by inflammation, pruritus and dryness of the skin. Diminished quality of life, sleeping problems and intense chronic pruritus are among the consequences faced by patients with atopic dermatitis, especially those with moderate to severe presentations of the disease.