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Background Chronic sinusitis is one of the most prevalent chronic illnesses affecting persons of all age groups. It is an inflammatory process that involves the paranasal sinuses and persists for 12 weeks or longer. Purpose The aim of this study was to investigate the effect of chronic rhinosinusitis (CRS) on sleep-disordered breathing. Patients and methods This study was conducted prospectively during the period spanning from June 2017 to June 2018 on 100 patients with CRS who attended to the ENT Departments of El-Maadi Armed Forces Medical Complex, Kobry El-Kobba Armed Forces Medical Complex, and El-Demerdash Hospitals. An additional 10 control patients were included in the study. All these patients gave informed consent to participate in this study. Results As regards apnea–hypopnea index, a comparative study between preoperative and postoperative measurements revealed a nonsignificant difference (P>0.05). As regards snore index and snore episodic measurements, the comparative study between preoperative and postoperative measurements revealed a highly significant decrease (P<0.01). As regards sleep efficiency and minimal and basal oxygen saturation measurements, the comparative study between preoperative and postoperative measurements revealed a highly significant increase (P<0.05). Conclusion Surgery decreased snoring and Epworth Sleepiness Scale scores, increased sleep efficiency and minimal and basal oxygen saturation measurements without changes in the apnea–hypopnea index, and improved sleep quality.

Background: Chronic Rhinosinusitis (CRS) can be subdivided into 2 major categories; CRS with or without nasal polyps (CRSwNP or CRSsNP) . IL-25 has been implicated in promoting Th2 responses in airway inflammation, However the clinical relevance of local IL-25 in CRS patients remains relatively uncharacterized. Objective: The aim of this work is to evaluate the relation between IL-25 and types of CRS. Subjects and Methods: This is a prospective study on 120 patients (60 CRSwNP, 60 CRSsNP) and 20 controls. All underwent clinical and radiological assessment. Biopsies from their nasal mucosa were taken for pathological assessment to detect mucosal changes, tissue eosinophilia and percentage and intensity of immunohistochemical IL-25 staining in tissues, and for correlation with clinical and radiological criteria. Results: CRSwNP patients are more associated with asthma, higher nasal endoscopy score, more severe inflammatory pathology, partial epithelial degeneration and ulceration and IL-25 tissue levels than CRSsNP and control group. 46% of patients with CRSwNP had tissue eosinophilia which is significantly higher than CRSsNP and control groups. We also found that the total nasal symptom score (TNSS), CT score and basement membrane thickness had a statistically significant positive correlation with immunohistochemical score of IL 25. Conclusion:This study shows increase in IL25 expression and tissue eosinophilia in CRSwNP when compared to CRSsNP and control group. Thus, IL-25 may be a promising therapeutic target and an indicator for the management of CRSwNP patients.