Objectives: the purpose of this study was to compare the outcomes of Resorbable bioactive glass UNIGRAFT® alone in comparison with those combined with autologous platelets rich fibrin (PRF) on the bone regeneration after treatment of maxillary odontogenic cysts.Patients and Methods: A total of twelve patients suffering from large maxillary odontogenic cysts were randomly assigned into two groups, each group were formed of six patients. Enucleation with peripheral ostectomy was done. The bony defects were grafted by application of Resorbable bioactive glass (Unigraft; Unicare Biomedical, Laguna Hills, CA) UNIGRAFT® alone in group (I) while in group (II) UNIGRAFT® mixed with Platelet Rich Fibrin.Clinical assessment was performed in the postoperative follow up including, Pain and swelling scores which was measured using VAS at 1 weeks. Radiographic examination measuring the bone density of the bony defects using cone beam computerized tomography (CBCT) at 3 and 6 months post-operative follow up.Results: all cases were healed without any signs of postoperative complications. Results showed that after 3 and 6 months, group (II) had significantly higher values than group (I) (p<0.05). Within both groups, there was a significant difference between densities measured at different intervals, with value measured after 6 months being higher significant than pre-operative value (p<0.05). Conclusion:UNIGRAFT® mixed with PRF improved the bone quality rather than UNIGRAFT® alone.