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Condensation of Wittig reagents 1a,b with arylhydrazones 2a,b by conventional and by microwave heating techniques furnished the corresponding pyridazines 3a‐e. The arylhydrazones 7a,b were allowed to react with 1a,b under the same conditions to produce the pyridazinones 10a,b and iminopyridazines 11a,b respectively. On the other hand, the arylhydrazones 12a‐c reacted with 1a to afford the pyridazinones 13a‐c. Treatment of 3b with dimethylformamide dimethyl acetal (DMFDMA) produced the adduct 15. The utility of microwave heating technique led to the reduction of the reaction times to few minutes and to the improvement of the yields of the products. The in vitro biological activity of some newly prepared compounds against four types of fungi was studied.

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Pyridazine derivatives R 0500Microwaves in Organic Synthesis: Facile Synthesis of Biologically Active Pyridazinone and Iminopyridazine Derivatives. -The condensation of Wittig reagents (II) with various hydrazones such as (I), (VI), or (IX) under microwave irradiation or with conventional heating is studied. Some of the products, e.g. (IIIb), show significant antifungal activity. -(MOHAMED*, N. R.; EL-SAIDI, M. M. T.; ALI, Y. M.; ELNAGDI, M. H.; J. Heterocycl. Chem. 44 (2007) 6, 1333-1337; Photochem. Dep., Natl. Res. Cent., Dokki, Giza, Egypt; Eng.) -M. Bohle 12-162

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