No abstract

Amenamevir has been approved for the treatment of herpes zoster (HZ); however, its therapeutic efficacy against central nervous system (CNS) infection may be insufficient due to its low spinal fluid permeability. We herein report a case of aseptic meningitis in a 91-year-old Japanese man treated with amenamevir for HZ in the trigeminal nerve region. Several cases of CNS infection have been reported in patients receiving amenamevir treatment for HZ. Patients with CNS complications often have skin rashes near the trigeminal region. Thus, we should be alert for signs of CNS infection when administering amenamevir to patients with such rashes.

Although central venous catheters (CVCs) play an important role in medical practice, their placement as foreign objects in the human body increases the risk of infection. Microbial colony and biofilm formation are likely to occur on CVCs. Infections caused by CVCs are referred to as catheter-related infections (CRIs), and can lead to longer hospital stays, increased medical costs, and in severe cases, bacteremia and death. The use of antimicrobial-impregnated catheters is recommended as a method to control CRIs. The efficacy of antimicrobial-impregnated catheters has been studied in basic experimental and clinical trials, but further improvements are still being sought, leading to studies on various combinations of iron chelators and antimicrobial agents to limit microbial and biofilm activity. Here, we hypothesize that a new type of CVC with an iron chelator in addition to antimicrobial agents might further suppress the occurrence of CRIs. This paper discusses the antimicrobial and anti-biofilm activities of iron chelators and proposes the possibility of creating a new type of CVC.

No abstract

No abstract