These findings provide a clue on the crucial role of haemoglobin molecule for senescent cell recognition or homeostasis in the blood circulation.

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The effects of lidocaine on chemical composition of membrane phospholipids and membrane fluidity of Streptococcus mutans have been studied. Increasing concentra‐tions of lidocaine induced both an increase in cardiolipin and a decrease in the degree of unsaturation of its fatty acid composition. A lidocaine‐dependent decrease of membrane fluidity was observed from an electron spin resonance spectroscopic study. It was considered thal bacteria grown with lidocaine below its minimum inhibitory concentration resisted the effect of the drug by modifying phospholipid and fatty acid composition resulting in a decreased membrane fluidity.

+ αβtcr + cells (cD57 + t cells), showed a significant inverse correlation with pB-IFn-γ-producing capability. the present results suggest that an increase in cD4 + cD57 + t cells controls the capability of pB to produce the antitumor cytokine IFn-γ and that pB-IFn-γ production is impaired with Hcc tumor progression. IntroductionHepatocellular carcinoma (HCC) is the fifth most common cancer in men and the eighth most common cancer in women worldwide. Hcc is highly prevalent in patients with chronic liver diseases resulting mainly from hepatitis B virus (HBV) or hepatitis c virus (HcV) infection, and its incidence is now increasing. In Japan, Hcc is the third most common cause of mortality, and the most frequent cause of Hcc is chronic infection with HcV (1,2 A b b re vi a t i o n s:A lt, a la n i n e t r a n s a m i n a s e; A F p, α