ABSTRACT. The feasibility of replacing fish meal protein at different levels with poultry by product meal food grade (PBM-FG) was assessed in diets for spotted rose snapper Lutjanus guttatus. Four diets were formulated, the control diet fish meal was used as the main protein source (FM); the other three diets had increasing levels of PBM-FG replacing 25, 50 or 75% of the fish meal protein respectively. The diets were fed close to apparent satiation, three times a day to quadruplicate groups of juvenile snapper (average body weight 11.0 ± 0.04 g). The fish were randomly distributed into groups of 15 fish in a 120 L seawater tank. The response of snapper to diets containing graded levels of fish meal was evaluated by measuring weight gain, feed efficiency, body composition, hematological parameters and apparent nutrient digestibility during a 12-week period. The replacing of the 25% of fish meal protein by PBM-FG did show a similar trend for feed efficiency and growth performance than control diet. Feed efficiency and growth performance was reduced at 75% level of fish meal protein replacement by PBM-FG, due to deficiencies of lysine and methionine. The final whole-body proximate composition did not differ among treatments. The hematological characteristics were similar among the treatments control, 25 and 50%, but the fish fed PBM-FG 75% showed the lowest levels for total protein and glucose parameters. The dietary dry matter and protein apparent digestibility coefficients (ADCs) decreased with increasing dietary PBM-FG. High values for lipid ADCs were observed in all diets. Keywords: artificial diets, hematological characteristics, amino acids, digestibility, aquaculture.Reemplazo de la harina de pescado por harina de subproducto de ave, grado alimento, en dietas para juveniles de pargo lunarejo (Lutjanus guttatus) RESUMEN. La factibilidad de la sustitución de la proteína de harina de pescado por proteína de ave, grado alimento (PBM-FG), fue evaluada en dietas para pargo lunarejo Lutjanus guttatus. Se formularon cuatro dietas, en la dieta control la harina de pescado (FM) se utilizó como principal fuente de proteína. Las otras tres dietas tenían crecientes niveles de PBM-FG en reemplazo del 25, 50 y 75% de la proteína de FM respectivamente. Las dietas fueron ofrecidas a saciedad aparente, tres veces al día a grupos de cuatro réplicas de juveniles (peso corporal promedio 11,0 ± 0,04 g). Los peces fueron distribuidos aleatoriamente en grupos de 15 peces en estanques de 120 L de agua de mar. La respuesta del pargo a las dietas, contenidas con niveles graduales de harina de pescado, fue evaluada midiendo la ganancia en peso, eficiencia del alimento, composición corporal, parámetros hematológicos y digestibilidad aparente de nutrientes durante un periodo de 12 semanas. El reemplazo del 25% de la proteína de FM por PBM-FG mostró una tendencia similar para la eficiencia del alimento y el desempeño productivo que la dieta control. La eficiencia del alimento y el rendimiento productivo fueron reducidos a un nivel de 75% ...