An efficient Cs CO -catalyzed oxidative coupling of thiols with phosphonates and arenes that uses molecular oxygen as the oxidant is described. These reactions provide not only a novel alkali metal salt catalyzed aerobic oxidation, but also an efficient approach to thiophosphates and sulfenylarenes, which are ubiquitously found in pharmaceuticals and pesticides. The reaction proceeds under simple and mild reaction conditions, tolerates a wide range of functional groups, and is applicable to the late-stage synthesis and modification of bioactive molecules.
Although the application of 1,2-dichloroethane (DCE) as ac hlorinating reagent in organic synthesis with the concomitant release of vinyl chloride as au seful byproduct is afantastic idea, it still presents atremendous challenge and has not yet been achieved because of the harsh dehydrochlorination conditions and the sluggish C À Hc hlorination process.Here we report ab ifunctional electrocatalysis strategy for the catalytic dehydrochlorination of DCE at the cathode simultaneously with anodic oxidative aromatic chlorination using the released HCl as the chloride source for the efficient synthesis of value-added (hetero)aryl chlorides.T he mildness and practicality of the protocol was further demonstrated by the efficient late-stage chlorination of bioactive molecules.
In
contrast to the recent breakthrough in electrochemical C–H
aminations, the electrochemically oxidative C–N bond formation
through a C–C bond cleavage is rarely studied. This work describes
an electrochemical C–C amination of alkylarenes for the efficient
synthesis of versatile anilines, as well as carbonyl compounds. With
the cheap and durable graphite plates as electrodes, and in a simple
undivided cell, this protocol is much more economical with the consumption
of electricity.
An efficient Cs 2 CO 3 -catalyzed oxidative coupling of thiols with phosphonates and arenes that uses molecular oxygen as the oxidant is described. These reactions provide not only an ovel alkali metal salt catalyzeda erobic oxidation, but also an efficient approacht ot hiophosphates and sulfenylarenes,w hich are ubiquitously found in pharmaceuticals and pesticides.T he reaction proceeds under simple and mild reaction conditions,t olerates aw ide range of functional groups,a nd is applicable to the late-stage synthesis and modification of bioactive molecules.Supportinginformation and the ORCID identification number(s) for the author(s) of this article can be found under: http://dx.
Dielectric elastomer actuators (DEAs) generate motion resembling natural muscles in reliability, adaptability, elongation, and frequency of operation. They are highly attractive in implantable soft robots or artificial organs. However, many applications of such devices are hindered by the high driving voltage required for operation, which exceeds the safety threshold for the human body. Although the driving voltage can be reduced by decreasing the thickness and the elastic modulus, soft materials are prone to electromechanical instability (EMI), which causes dielectric breakdown. The elastomers made by cross-linking bottlebrush polymers are promising for achieving DEAs that suppress EMI. In previous work, they were chemically cross-linked using an in situ free-radical UV-induced polymerization, which is oxygen-sensitive and does not allow the formation of thin films. Therefore, the respective actuators were operated at voltages above 4000 V. Herein, macromonomers that can be polymerized by ring-opening metathesis polymerization and subsequently cross-linked via a UV-induced thiol−ene click reaction are developed. They allow us to fast cross-link defect-free thin films with a thickness below 100 μm. The dielectric films give up to 12% lateral actuation at 1000 V and survive more than 10,000 cycles at frequencies up to 10 Hz. The easy and efficient preparation approach of the defect-free thin films under air provides easy accessibility to bottlebrush polymeric materials for future research. Additionally, the desired properties, actuation under low voltage, and long lifetime revealed the potential of the developed materials in soft robotic implantable devices. Furthermore, the C−C double bonds in the polymer backbone allow for chemical modification with polar groups and increase the materials' dielectric permittivity to a value of 5.5, which is the highest value of dielectric permittivity for a cross-linked bottlebrush polymer
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.