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The paper presents scientific information about the problems in the search for therapeutic potential in coniferous plants widely used in folk medicine. Samples of  coniferous plants growing in the mountain forests of the Western Altai in the eastern part of Kazakhstan were selected for the experiment: Baltic pine (Pinus sylvestris L.), European spruce (Picea abies L.), Siberian fir (Abies sibírica), Siberian pine (Pinus sibirica DuTour), and common juniper (Juniperus communis L.). During the study, the phytochemical composition of the components of P. sylvestris L. essential oils was determined by the indicators of sesquiterpenic fraction (69.76%), terpenoids (20.0%), and monoterpenes (5.51%). Using modern methods of studying biological activity (antimicrobial, antifungal, and anthelmintic), the authors established the presence of biological activity in the extracts of selected coniferous plants. In all coniferous plants, bactericidal activity was manifested in water decoctions, where biological preparations of Siberian fir and Baltic pine were more active. The oil extracts showed less bactericidal activity. Among them, extracts of Siberian pine and juniper were inactive, and the extract of European spruce was more active in its native form and 1:2 dilution. Among plants with a complete absence of bactericidal activity against the Candida parapsilosis opportunistic yeast, Siberian fir should be named. In other coniferous plants (European spruce, Baltic pine, juniper), bactericidal activity was detected only in oil solutions in a dilution of 1:2, and oil extract of Siberian pine in a dilution of 1:8 had a suppressive effect. Water/alcohol tincture of Siberian fir was found to have high fungicidal activity against Aspergillusniger, which continued to influence the growth of the micromycete at a dilution of 1:64 during the observation period. The presence of antiparasitic properties was observed in some plant extracts of coniferous forest plants. The best results were noted in alcohol tinctures of Baltic pine, juniper, and Siberian pine.

We report the first case of non-dermatophytic onychomycosis of the toenail described in Kazakhstan caused by Candida parapsilosis. The biological properties of the strain were studied. C. parapsilosis forms white creamy colonies, smooth with focal wrinkles, and the reversum is light-yellow. The culture of C. parapsilosis is represented by a yeast form, characterized by the presence of round or cylindrical yeast cells with active budding. The strain has a high saccharolytic and urease activity and is indifferent to the sucrose and maltose. The C. parapsilosis strain was sensitive to polyene and azole antifungal agents. The highest sensitivity was found to ketoconazole, itraconazole and nystatin.

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