Objectives: To investigate the relationship between the concentration of urinary soluble urokinase plasminogen activator (suPAR) pretreatment with the treatment responsiveness in children with primary nephrotic syndrome. Methods: Longitudinal follow-up study. Results: A study of 30 children diagnosed with the initial nephrotic syndrome was followed up at Hue Pediatric Center of Hue Central Hospital and Pediatrics Departement of Hue University of Medicine and Pharmacy Hospital. Urinary suPAR/creatinine ratio was 2712 ± 2217 pg/mg (605 - 11443 pg/mg), urinary suPAR/creatinine ratio in children 1-6 years old was significantly higher than that in group 7-15 years old, there was no signifficant difference about urinary suPAR between hematuria and non-hematuria group. Urinary suPAR/creatinine ratio was not significantly associated with serum albumin, glomerular filtration rate and proteinuria. After 2 months of steroid treatment, 100% patients was completely remission. Following- up 28 patients after 6 months of steroid treatment: the rate of completely remission, infrequent relapse and frequent relapse were 67.8%, 25% and 7.2% respectively, there was no signifficant difference about urinary suPAR/creatinine ratio among three groups. Conclusions: Pre-treatment urinary suPAR/creatinine ratio do not help predict the ability of steroid responsiveness in the early period of treatment. More research is needed to understand more the role of urinary suPAR in pediatric nephrotic syndrome. Key words: soluble urokinase plasminogen activator, urinary suPAR, childhood nephrotic syndrome

A 18-month-old-girl presented with five months history of progressive edema and pallor. Nutritional his-tory revealed long-standing excessive cow milk intake. She was found to be profoundly severe iron deficiency anemia and hypoproteinemic, gastroendoscopy revealed many lessions in duodenum. RIDA qLine Allergy test is positive with cow milk, casein and bovin serum albumin. She was treated with cow milk restriction and oral iron supplements, which resulted in resolution of her edema and laboratory anomalies within two month. Cow’s milk allergy frequently presents with eczema, diarrhea, wheezing…while iron deficiency and hypopro-teinemic are quite rare. We report this case with the aim of providing clues for pediatricians for diagnosis and treatment of this disease. Key words: edema, hypoproteinemic, iron deficiency, cow’s milk allergy