The main objective of this review is to describe the health effects of commonly used laboratory volatile solvents in institutional laboratories. The most commonly used laboratory solvents such as petroleum ether, methanol, diethyl ether, benzene, acetone, mercury, etc. are having moderate to severe health effects on user. The mode of exposure and duration exposure of volatile solvents has greater effect on user. In a laboratory, when students/ researcher doing experiment unknowingly they are getting exposed with volatile solvents which has grater health (adverse) effect. The severity of the adverse effect varies based on type of exposure and duration exposure. The undesired effects of laboratory volatile solvents are sometime irreversible and may cause life-threatening problems.