This study aimed to isolate polyprenylated benzophenones from the rootbark of Garcinia celebica and assess their activities in vitro and in silico. The antioxidant activity was evaluated by the DPPH, ABTS, and FRAP methods. The cytotoxicity was evaluated against HeLa, MCF-7, A549, and B16 cancer cell lines. The antiplasmodial activity was performed against the chloroquine-sensitive Plasmodium falciparum strain 3D7. Molecular docking was analyzed on alpha-estrogen receptor (3ERT) and P. falciparum lactate dehydrogenase enzyme (1CET). The prediction of ADMET for the compounds was also studied. For the first time, (-)-cycloxanthochymol, isoxanthochymol, and xanthochymol were isolated from the root bark of Garcinia celebica. The antioxidant and cytotoxicity evaluation showed that all benzophenones exhibited antioxidant activity compared to gallic acid and quercetin as positive controls and also exhibited strong activity against HeLa, MCF-7, A549, and B16 cell lines compared to cisplatin as the positive control. The antiplasmodial evaluation showed that isoxanthochymol exhibited activity against the chloroquine-sensitive P. falciparum strain 3D7. In addition, the in silico molecular docking study supported in vitro activities. The ADMET analysis also indicated the isolated benzophenones are potential oral drug candidates.

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Dewaka's banana grows well and abundant bananas production in Merauke area, but with a little bit sour taste when they're ripe made this bananas often the second choice compared to another kind of bananas. The research has been conducted to determine concentration of bioethanol produced from dewaka's banana flour. Banana flour was obtained from crused the slices of dried bananas. Then concentration of ethanol can then be identified through a series of tests in the laboratory. The results of gas chromatographic analysis show that dewaka banana can be used as an alternative energy source with bioethanol content of 83.43%. The concentration was result of 5 (five) days fermentation with yeast. The hydrolysis which is used was acid hydrolysis, using hydrochloric acid. The optimum concentration of hydrolysis was 1.5 N HCl, the optimum temperature was 90 0 C, whereas the optimum hydrolysis time was 70 minutes.