Hyaluronic acid-C-niosomes might provide a promising gene delivery system for successful retinal gene therapy.

We predicted a new ternary hydride Li 2 SiH 6 at high pressures. A systematic structure search in Li 2 SiH 6 compound reveals novel stable phases with intriguing electronic and phonon properties.It is found that Li 2 SiH 6 is dynamically stable from ambient pressure up to 400 GPa with three novel phases: P312, P 3, and P 62m. The calculation of electron-phonon coupling combined with Bardeen-Cooper-Schrieffer's argument indicates that this compound may be a candidate for high T c superconductors under high pressures. In particular, the maximum T c of P 62m-Li 2 SiH 6 at 400 GPa reaches 56 K. These findings may pave the way for obtaining room temperature superconductors in dense hydrogen-rich compounds. INTRODUCTIONThe search for high-temperature superconducting materials has always been a hot topic in the field of condensed matter physics. According to the traditional Bardeen-Cooper-Schrieffer (BCS) theory[1], the superconducting transition temperature is directly proportional to the Debye temperature, and the Debye temperature is inversely proportional to the mass, so lighter elements may have higher superconducting transition temperatures, such as hydrogen. However, solid hydrogen is an insulating molecular crystal under ambient pressure, and there are strong covalent bonds in hydrogen molecules, so it is hard to obtain superconducting hydrogen under ambient pressure. In order to achieve superconductivity, conditions such as external pressure are needed. As a basic thermodynamic variable, pressure can change the distance between atoms of matter, so that atoms can be rearranged, and the crystal and electronic structure can be modulated. High pressure can very effectively shorten the distance between atoms, increase the overlap of adjacent electron orbits, and then change the interaction and electronic structure between atoms/molecules, forming high-pressure new phases with new structures and properties that are difficult to form under conventional conditions. Generally, in a sufficiently high pressure environment, the band gap will be narrowed, and the energy bands will overlap, which can transform the non-metallic state into the metallic state. Wigner and Huntington proposed that insulating hydrogen molecules can be transformed into metallic hydrogen under high pressure, showing a metallic state [2]. Ashcroft proposed chemical preloading [3], that is, non-hydrogen elements in hydrogen-rich compounds have an interaction effect on hydrogen elements in the

Alternative splicing produces different isoforms from the same gene locus, it is an important mechanism for regulating gene expression and proteome diversity. Although the prediction of gene(ncRNA)-disease associations has been extensively studied, few (or no) computational solutions have been proposed for the prediction of isoform-disease association (IDA) at a large scale, mainly due to the lack of disease annotations of isoforms. However, increasing evidences confirm the associations between diseases and isoforms, which can more precisely uncover the pathology of complex diseases. Therefore, it is highly desirable to predict IDAs. To bridge this gap, we propose a deep neural network based solution (DeepIDA) to fuse multi-type genomics and transcriptomics data to predict IDAs. Particularly, DeepIDA uses geneisoform relations to dispatch gene-disease associations to isoforms. In addition, it utilizes two DNN sub-networks with different structures to capture nucleotide and expression features of isoforms, Gene Ontology data and miRNA target data, respectively. After that, these two subnetworks are merged in a dense layer to predict IDAs. The experimental results on public datasets show that DeepIDA can effectively predict IDAs with AUPRC (area under the precision-recall curve) of 0.9141, macro Fmeasure of 0.9155, G-mean of 0.9278 and balanced accuracy of 0.9303 across 732 diseases, which are much higher than those of competitive methods. Further study on sixteen isoform-disease association cases again corroborates the superiority of DeepIDA. The code of DeepIDA is available at http://mlda.swu.edu.cn/codes.php?name=DeepIDA.

High-pressure structural searches of superhydrides CeBeH8 and CeBH8 were performed under ambient pressure up to 300 GPa. We identify Fm3m-CeBeH8 with a superconducting transition temperature Tc of 56 K at 10 GPa. Two more phases with spacegroup R3m and C2/m, were investigated within the increasing pressures. CeBH8 shows a similar phase transition process as CeBeH8 but with higher transition pressures and higher Tc. Fm3m-CeBH8 is predicted to be superconducting above 120 GPa with a maximum Tc of 118 K at 150 GPa. R3m-CeBH8 and C2/m-CeBH8 are dynamically stable above 120 GPa and 100 GPa, respectively. The maximum Tc is 123 K at 195 GPa for R3m-CeBH8, and 115 K at 350 GPa for C2/m-CeBH8. Our work enriches the family of ternary hydrides and may provide a useful guideline for further search for superconducting hydrides at low and moderate pressures.

High-pressure structural search was performed on the hydrogen-rich compound LuBeH8 at pressures up to 200 GPa. We found a Fm{overbar}3m structure that exhibits stability and superconductivity above 100 GPa. Our phonon dispersion, electronic band structure, and superconductivity analyses in the 100-200 GPa pressure range reveal a strong electron-phonon coupling in LuBeH8. While Tc shows a decreasing trend as the pressure increases, with a superconducting critical temperature Tc of 255 K at 200 GPa and a maximum Tc of 355 K at 100 GPa. Our research has demonstrated the room-temperature superconductivity in Fm{overbar}3m-LuBeH8, thus enriching the family of ternary hydrides. These findings provide valuable guidance for identifying new high-temperature superconducting hydrides.