In the recent years, researchers have contributed substantially in the field of Surface Plasmon Resonance (SPR) sensors and its applications. SPR sensors show the salient features, such as label-free detection, real-time monitoring, small sample size, furnish accurate outcomes at low cost, and smooth handling. Moreover, the SPR sensors are also well-known because of its quantitative and qualitative excellent performance in real-time applications, including drug discovery, environment monitoring, food safety, medical diagnosis, clinical diagnosis, biological studies, and biomolecule interactions. This paper exhibits a comprehensive review of SPR based sensors, such as prism-based SPR with the applications (e.g., biomolecule interaction, medical diagnostic, etc.), fiber-based SPR, and waveguide-based SPR. Furthermore, we summarized the modern designs and techniques with their limitations and challenges in detail. The erudition outlined in this paper can be given an exceptional benefit for the researchers and industry people in the field of SPR based sensors.

A novel, to the best of our knowledge, surface plasmon resonance (SPR) sensor, employing a silicon-barium titanate structure for Pseudomonas bacterial detection, is designed. Three bacterial attachments operate as a protective layer for the detection process with refractive indices (RI) of 1.437, 1.49368, and 1.5265. Performance analysis shows a sensitivity ( S ) of 155, 168, and 370°/RIU at RI of 1.5265 for Structures 1, 2, and 3, respectively. Additionally, the proposed sensor (Structure 3) accomplishes a magnified figure of merit (FOM) of 86.43 and quality factor of 86.65 at the RI of 1.5265. Finally, the proposed sensor’s performance is compared with that of the existing sensors, thus demonstrating a heightened S and FOM.

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We present the performance enhancement of the surface plasmon resonance (SPR) sensor for deoxyribonucleic acid (DNA) hybridization employing black phosphorus (BP), silver (Ag), and silicon (Si) configurations and numerical analysis. The combination of Ag and BP demonstrates the sensitivity of 91.54°/RIU with degradation of detection accuracy (DA), quality factor (QF), and figure of merit (FOM). To enhance the DA, QF, and FOM, a novel SPR is proposed with Si, which demonstrates a DA and QF of 69 and 1061.6 R I U − 1 , which are 8.53 and 11.04 times, and an FOM of 554.58, which is 4.47 and 5.77 times higher than both the conventional and graphene-based SPR sensors, respectively.

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