Development of methodological and axiological settings that contribute to the effectiveness of modern systems of knowledge control of pharmaceutical students in the system Moodle. The synergetic philosophical-scientific method was applied to provide a versatile consideration of the problems of using distance learning format. Demonstrated the active use of the Moodle learning environment by pharmacy students of these institutions of higher education. Elements, by means of which knowledge control was carried out, confirmed its effectiveness, since the results of knowledge assessment of students conducted in Moodle mostly coincided with the examinations and qualification examinations (in particular, KROK). Among the key guidelines, we note openness, implying the comprehensibility of tasks; dynamism, providing the possibility of changing or adjusting control tasks; the educational and pedagogical value of control forms, forming an effective system of assessment of knowledge and skills of students; compliance with moral and psychological standards when conducting control in the distance learning system Moodle. Prospects for further research we see the creation of an international unified system of control of the relevant branches of knowledge (in our case - pharmaceutical specialty) based on the initial environment Moodle.