Abstract. A method for the complex treatment of patients with chronic gingivitis is applied, including the application of trypsin in 1% solution of sodium bicarbonate, topical medication Qudesan and sonication, using a curette scaler with the toe. The clinical efficiency of the proposed method in the dynamics of treatment 55 patients with chronic gingivitis is counted. The use of complex therapy in accordance with the described method allows us to achieve a total destruction of the microbial biofilm in 7-8 days, which significantly improves the health and condition of the periodontal tissues, as well as the general condition of the patients after 2-3 weeks.

Abstract. The research objective consisted in studying the local factors of protection of an oral cavity on the basis of balance definition between proinflammatory (INf -γ, TNF -α, IL-8) and anti-inflammatory (IL-4) cytokines with the degree of colonization of Candida in patients with chronic generalized parodontitis. On the basis of the results of this study, it has been established that patients with chronic parodontitis who have a mild and moderate severity level of disease, a high degree colonization of periodontal pockets with Candida tropicalis correlates with a substantial increase in proinflammatory cytokines (TNF -α, IL-8), concentration fall of INF -γ and the increase in antiinflammatory cytokines of IL-4 level.