This article discusses the functions of grammar in relation to lexical semantics and sets out to undertake lexico-grammatical analysis of some physiological verbs in the Russian language. It demonstrates the interaction of lexical and grammatical senses of a word in its structure on a specific language material. The verbs under discussion are: есть -yest' (eat), пить -pit' (drink), лечить -lechit' (treat), беременеть -beremenet' (get pregnant), болеть -bolet' (be ill). This research is conducted by using descriptive-analytic method. It is worthwhile to find out to what extent verbal meanings can be presented through the system of grammatical categories. Lexico-grammatical characteristics of verbs with physiological meaning are presented within seven groups. Russian verbs have a number of categories which are not often taken into account in dictionaries. An attempt which brings together grammatical and semantic aspects of the verbs in a dictionary is made in this paper.