Background Pre‐incision wound infiltration using NSAID is an alternative method to manage post‐operative pain in surgery. It is postulated that NSAID delivered peripherally exerts efficient analgesic and anti‐inflammatory effect with minimal systemic complication. This study explored the efficacy of using diclofenac for wound infiltration in open thyroidectomy and parathyroidectomy as compared to conventional agent, bupivacaine. Methodology The study was designed as a double‐blind, randomized controlled trial involving 94 patients who underwent open thyroidectomy or parathyroidectomy in Hospital Pulau Pinang, Malaysia, from November 2015 to November 2016. The study compared the efficacy of pre‐incision wound infiltration of diclofenac (n = 47) versus bupivacaine (n = 47) in post‐operative pain relief. Wound infiltration is given prior to skin incision. Mean pain score at designated time interval within the 24‐h post‐operative period, time to first analgesia, total analgesic usage and total analgesic cost were assessed. Results Ninety‐four patients were recruited with no dropouts. Mean age was 49.3 (SD = 14.2) with majority being female (74.5%). Ethnic distribution recorded 42.6% Chinese, 38.3% Malay, followed by 19.1% Indian. Mean duration of surgery was 123.8 min (SD = 56.5), and mean length of hospital stay was 4.7 days (SD = 1.8). The characteristics of patient in both groups were generally comparable except that there were more cases of total thyroidectomy in the diclofenac group (n = 31) as compared to the bupivacaine group (n = 16). Mean pain score peaked at immediate post‐operative period (post‐operative 0.5 h) with a score of 3.5 out of 10 and the level decreased steadily over the next 20 h starting from 4 h post‐operatively. Pre‐incision wound infiltration using diclofenac had better pain control as compared to bupivacaine at all time interval assessed. In the resting state, the mean post‐operative pain score difference was statistically significant at 2 h [2.1 (SD = 1.5) vs. 2.8 (SD = 1.8), p = 0.04]. During neck movement, the dynamic pain score difference was statistically significant at post‐operative 1 h [2.7 (SD = 1.9) vs. 3.7 (SD = 2.1), p = 0.02]; 2 h [2.7 (SD = 1.6) vs. 3.7 (SD = 2.0), p = 0.01]; 4 h [2.2 (SD = 1.5) vs. 2.9 (SD = 1.7), p = 0.04], 6 h [1.9 (SD = 1.4) vs. 2.5 (SD = 1.6), p = 0.04] and 12 h [1.5 (SD = 1.5) vs. 2.2 (SD = 1.4), p = 0.03]. Mean dose of tramadol used as rescue analgesia in 24 h duration was lower in the diclofenac group as compared to bupivacaine group [13.8 mg (SD = 24.9) vs. 36.2 mg (SD = 45.1), p = 0.01]. The total cost of analgesia used was significantly cheaper in diclofenac group as compared to bupivacaine group [RM 3.47 (SD = 1.51) vs. RM 13.43 (SD = 1.68), p < 0.01] or [USD 0.83 (SD = 0.36) vs. USD 3.21 (SD = 0.40), p < 0.01]. Conclusion Pre‐incision wound infiltration using diclofenac provides better post‐operative pain relief compared to bupivacaine for patient who had underwent open thyroidectomy or parathyroidectomy. Diclofenac is cheap and easily a...

Renal cell carcinomas (RCCs) commonly metastasize to the lungs and bones and rarely to the parathyroid, maxillary sinus, and adrenals. It is indeed very rare to have these all these metastases occurring simultaneously in an individual. We share a case of 67-year-old woman provisionally treated for parathyroid carcinoma but subsequently found to actually have metastatic RCC to the left maxillary sinus, parathyroid, lungs, and adrenals on 18F-fluorodeoxyglucose positron emission tomography–computed tomography.

24.0%) cases were confirmed to be positive. Multivariable analysis revealed that LNM was associated with head/uncinate location (p=0.021), largest tomur size>2cm (p=0.004), increasing tumor grade (p=0.021), lymph vascular invasion (p<0.001) and distant metastasis (p=0.001). With a median follow up of 34.5 months, 144 (13.5%) patients recurred and 124 (11.6%) patients died of disease progression. The median OS of N1 group was 127.2 moths, which was significantly shorter than N0/Nx group (176.4 months, p<0.001). For patients underwent curative resection (R0/R1, n=1012), the median RFS in N0/Nx group was also superior to N1 group (not reached vs. 91.1 months, p<0.001). In addition, number of positive lymph node>5 was associated with worse OS (p=0.013). Lymphadenectomy was mostly performed in distal pancreatectomy (59.9%), tumor size >2cm (89.7%), and grade G3 (93.8%). The median OS in Nx group (190.9 months) was similar to N0 group (176.4 months, p=0.265). Conclusion: LNM are valuable predictor of poor outcomes for pNETs. Surgery without LA is safe in selected patients with small G1 lesions, normal sized and soft lymph nodes.