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Background. Chronic obstructive pulmonary disease (COPD) patients are particularly vulnerable to acute exacerbation, resulting in a huge socioeconomic burden. Objective. In this study, we evaluated the value of serum secreted frizzled-related protein 1 (SFRP1) and Clara cell-secreted protein (CC16) in predicting the risk of acute exacerbations in patients with COPD. Methods. The study included 123 COPD patients admitted to our hospital from May 2020 to June 2021, including 65 patients in stable stage (STCOPD group), 58 patients in acute exacerbation stage (AECOPD group), and 60 healthy volunteers (control group). Serum SFRP1 and CC16 levels were detected by enzyme-linked immunosorbent assay (ELISA). The receiver operating characteristics curve (ROC) analysis was performed to evaluate the sensitivity and specificity of serum SFRP1 and CC16 for predicting the risk of acute exacerbation in COPD patients. Results. The age among groups is significantly different, but there is no difference in the gender and body mass index (BMI). The level of serum SFRP1 in the AECOPD group was significantly higher than that in the STCOPD group and the control group, and the level of serum CC16 was lower than that in the STCOPD group and the control group. Serum SFRP1 was negatively correlated with forced expiratory volume in one second (FEV1)/forced vital capacity (FVC) (r = −0.473, P < 0.001 ). Serum CC16 was positively correlated with FEV1/FVC (r = 0.457, P < 0.001 ). The area under the curve (AUC), sensitivity, and specificity of SFRP1 for predicting the risk of exacerbation was 0.847 (95% CI: 0.775 to 0.920), 86.20%, and 80.00%. The AUC, sensitivity, and specificity of CC16 for predicting the risk of exacerbation were 0.795 (95% CI: 0.711 to 0.879), 74.10%, and 86.20%. Conclusions. These findings suggest that SFRP1 and CC16 may be useful serum markers for predicting the risk of exacerbation in COPD patients.

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Two coordination polymers (CPs) based on Co(II), [Co(L)(bipy)] ·3H2O (1), and [Co(L)(phen)(MeOH) (H2O)2] · 0.5H2O (2) were successfully generated under solvothermal reactions. These CPs were characterized via infrared spectroscopy, elemental analysis, single-crystal X-ray diffraction, and X. The regulation of these CPs’ structures was compared by introducing different lengths of nitrogen-donor auxiliary ligands. The corresponding mechanism in the regulation of these structures was elucidated. The CPs’ suppression activity against the release of inflammatory cytokines was detected via ELISA. Subsequently, the relative expression of p53 and nf-κb in immune cells after treatment with the CPs was detected via real-time PCR. Finally, the application value of these novel CPs in sepsis therapy was explored.

The viscose fibers were modified by Polyamidoamine (PAMAM) which was one kind of cationic modifier in proportion with wet spinning. The surface morphological and chemical properties of modified viscose fibers were characterized by Fourier transform infrared spectroscopy (FTIR) and Scanning electron microscope (SEM). The dyeing property and adsorption isotherm of the modified viscose fiber with active dark blue K-R were investigated. The washing fastness, breaking strength and hygroscopic performance were carried out at a constant temperature. The research results show that the physical structure and chemical properties of the viscose modified by a little amount of PAMAM were not affected. With the increasing of the amount of PAMAM increased in viscose fiber, the main adsorption and dyeing mechanism of viscose fiber has been changed from Freundlich-type physical nonlocalized adsorption to Langmuir-type chemical localized adsorption. The breaking strength and washing fastness of viscose fiber has no effect on with the addition of PAMAM. The cationic modifier PAMAM can increase the dyeing rate and percentage of dyeing of viscose fiber, which is of great significance for improving viscose fiber dyeing process.