A cascade reaction of 2-alkynylbenzaldehydes and 2-(4,5-diphenyl-1Himidazol-2-yl)aniline was treated in DMF catalyzed by AgOTf leading to 6,13,14-triaryl-11bH-imidazo[1,2-c] isoquinolino[2,1-a]quinazolines in high yields. This Domino reaction included condensation, cyclization, and acetylenic hydroamination under mild conditions to build fused pentacyclic heterocycle with three new bonds and two new rings.

Aldehyde could undergo not only the subsequent condensation and cyclization with 2‐aminothiophene‐3‐carboxamide to build a pyrimidine ring, but also a Friedel‐Crafts alkylation reaction with thiophene moiety to give unexpected 6‐benzyl‐2‐arylthieno[2,3‐d]pyrimidin‐4(3H)‐ ones in good yields catalyzed by concentrated HCl.