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Osteosarcoma is the most common primary bone sarcoma that mostly occurs in young adults. The causes of osteosarcoma are heterogeneous and still not fully understood. Identification of novel, important oncogenic factors in osteosarcoma and development of better, effective therapeutic approaches are in urgent need for better treatment of osteosarcoma patients. In this study, we uncovered that the oncogene MYC is significantly upregulated in metastastic osteosarcoma samples. In addition, high MYC expression is associated with poor survival of osteosarcoma patients. Analysis of MYC targets in osteosarcoma revealed that most of the osteosarcoma super enhancer genes are bound by MYC. Treatment of osteosarcoma cells with super enhancer inhibitors THZ1 and JQ1 effectively suppresses the proliferation, migration, and invasion of osteosarcoma cells. Mechanistically, THZ1 treatment suppresses a large group of super enhancer containing MYC target genes including CDK6 and TGFB2. These findings revealed that the MYC-driven super enhancer signaling is crucial for the osteosarcoma tumorigenesis and targeting the MYC/super enhancer axis represents as a promising therapeutic strategy for treatment of osteosarcoma patients.

Phononic crystals (PCs) and metamaterials (MMs) can exhibit abnormal properties, even far beyond those found in nature, through artificial design of the topology or ordered structure of unit cells. This emerging class of materials has diverse application potentials in many fields. Recently, the concept of tunable PCs or MMs has been proposed to manipulate a variety of wave functions on demand. In this review, we survey recent developments in tunable and active PCs and MMs, including bandgap and bandgap engineering, anomalous behaviors of wave propagation, as well as tunable manipulation of waves based on different regulation mechanisms: tunable mechanical reconfiguration and materials with multifield coupling. We conclude by outlining future directions in the emerging field.

a b s t r a c tIn this paper, the elastic wave propagation in phononic crystals with piezoelectric and piezomagnetic inclusions is investigated taking the magneto-electro-elastic coupling into account. The electric and magnetic fields are approximated as quasi-static. The band structures of three kinds of piezoelectric/piezomagnetic phononic crystals-CoFe 2 O 4 /quartz, BaTiO 3 /CoFe 2 O 4 and BaTiO 3 -CoFe 2 O 4 /polymer periodic composites are calculated using the plane-wave expansion method. The piezoelectric and piezomagnetic effects on the band structures are analyzed. The numerical results show that in CoFe 2 O 4 /quartz structures, only one narrow band gap exists along the C-X direction for the coupling of xy-mode and z-mode for the filling fraction f being 0.4; while in BaTiO 3 /CoFe 2 O 4 composites, only one narrow band gap exists along the C-X direction forxy-mode and no band gap exists for z-mode as the filling friction f is 0.5. Moreover, for the new type of magneto-electroelastic phononic crystal-BaTiO 3 -CoFe 2 O 4 /polymer periodic composite, the band gap characteristics are more superior in the whole considered frequency regions due to the big contrast of the material properties in the two constituents and the effects of the piezoelectricity and piezomagneticity on the band gap structures are remarkable.